Matches in DBpedia 2014 for { <http://dbpedia.org/resource/HLA_A1-B8-DR3-DQ2> ?p ?o. }
- HLA_A1-B8-DR3-DQ2 abstract "HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype) is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6 (not to be confused with the HLA-DQ heterodimer DQ8.1). A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are generally the result of descent by common ancestry (share a recent common ancestor for that segment of the chromosome). Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations.The haplotype can be written in an extended form covering the major histocompatibility loci as follows:HLA A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201 or shorthand A1::DQ2There are many other gene-alleles within the haplotype, including more than 250 coding loci that produce transcripts.At 4.7 million nucleotides in length, A1::DQ2 is the second longest haplotype identified within the human genome. A1::DQ2 creates a conundrum for the evolutionary study of recombination. The length of the haplotype is remarkable because of the rapid rate of evolution at the HLA locus should degrade such long haplotypes. A1::DQ2's origin is difficult to trace, suggestions of a common ancestor in Iberia or Africa have been put forward. Although its place of origin is not certain there is agreement that bearers of the European AH8.1 bear a haplotype related by a common descent. A1::DQ2 is the most frequent haplotype of its length found in US Caucasians, ~15% carry this common haplotype.Studies indicate that A1::DQ2 prominence is likely due to positive selection in the pre-Neolithic period and isolation in countries were wheat was not a prominent cereal. Outside of DR3-DQ2 with known associations to autoimmune disease, other factors within A1::DQ2 are believed to also contribute to autoimmune disease. Also a dozen inflammatory diseases of the immune system can attribute some risk to the haplotype. Some disease like coeliac disease primarily associate with certain genes. While other diseases, like type 1 diabetes may have several, highly different, genes that attribute risk. Still other diseases, like myasthenia gravis have undetermined linkage to the haplotype.".
- HLA_A1-B8-DR3-DQ2 thumbnail HLA-mini.png?width=300.
- HLA_A1-B8-DR3-DQ2 wikiPageExternalLink get_allele.cgi?MICA*00801.
- HLA_A1-B8-DR3-DQ2 wikiPageExternalLink get_allele.cgi?MICB*008.
- HLA_A1-B8-DR3-DQ2 wikiPageExternalLink journal.pgen.0020009.
- HLA_A1-B8-DR3-DQ2 wikiPageExternalLink abstract.
- HLA_A1-B8-DR3-DQ2 wikiPageID "18856281".
- HLA_A1-B8-DR3-DQ2 wikiPageRevisionID "603209289".
- HLA_A1-B8-DR3-DQ2 alias ""B*0801:DRB1*0301""".
- HLA_A1-B8-DR3-DQ2 alias ""B8-DR3"; "B8-DR3"".
- HLA_A1-B8-DR3-DQ2 alias ""Super-B8", "AH8.1", "ancestral MHC 8.1"".
- HLA_A1-B8-DR3-DQ2 chromosome "6".
- HLA_A1-B8-DR3-DQ2 disease Autoimmune_hepatitis.
- HLA_A1-B8-DR3-DQ2 disease Coeliac_disease.
- HLA_A1-B8-DR3-DQ2 disease Dermatitis_herpetiformis.
- HLA_A1-B8-DR3-DQ2 disease Diabetes_mellitus_type_1.
- HLA_A1-B8-DR3-DQ2 disease Myasthenia_gravis.
- HLA_A1-B8-DR3-DQ2 disease Primary_biliary_cirrhosis.
- HLA_A1-B8-DR3-DQ2 disease Sarcoidosis.
- HLA_A1-B8-DR3-DQ2 disease Systemic_lupus_erythematosus.
- HLA_A1-B8-DR3-DQ2 freqmax ">11.0%".
- HLA_A1-B8-DR3-DQ2 freqmax ">15.0%".
- HLA_A1-B8-DR3-DQ2 gene10name "HLA-DR".
- HLA_A1-B8-DR3-DQ2 gene10var "*0301".
- HLA_A1-B8-DR3-DQ2 gene1name HLA-A.
- HLA_A1-B8-DR3-DQ2 gene1name "HLA-B".
- HLA_A1-B8-DR3-DQ2 gene1var "B*0801".
- HLA_A1-B8-DR3-DQ2 gene2name HLA-C.
- HLA_A1-B8-DR3-DQ2 gene2name MHC_class_I_polypeptide-related_sequence_A.
- HLA_A1-B8-DR3-DQ2 gene2var "*0801".
- HLA_A1-B8-DR3-DQ2 gene3name HLA-B.
- HLA_A1-B8-DR3-DQ2 gene3name MICB.
- HLA_A1-B8-DR3-DQ2 gene3var "*0801".
- HLA_A1-B8-DR3-DQ2 gene4name HLA-DRB1.
- HLA_A1-B8-DR3-DQ2 gene4name Tumor_necrosis_factor_alpha.
- HLA_A1-B8-DR3-DQ2 gene4var "-".
- HLA_A1-B8-DR3-DQ2 gene5name HLA-DRB3_(gene).
- HLA_A1-B8-DR3-DQ2 gene5name Lymphotoxin_alpha.
- HLA_A1-B8-DR3-DQ2 gene5var "-".
- HLA_A1-B8-DR3-DQ2 gene6name C4A.
- HLA_A1-B8-DR3-DQ2 gene6name Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA_A1-B8-DR3-DQ2 gene6var "Null".
- HLA_A1-B8-DR3-DQ2 gene7name Complement_component_4B.
- HLA_A1-B8-DR3-DQ2 gene7name HLA-DQB1.
- HLA_A1-B8-DR3-DQ2 gene8name CYP21.
- HLA_A1-B8-DR3-DQ2 gene9name "HLA-DRB3".
- HLA_A1-B8-DR3-DQ2 gene9var "*0101".
- HLA_A1-B8-DR3-DQ2 haplotype HLA-DQ.
- HLA_A1-B8-DR3-DQ2 haplotype HLA_DR3-DQ2.
- HLA_A1-B8-DR3-DQ2 haplotype "B8-DR3".
- HLA_A1-B8-DR3-DQ2 haplotype "B8::DQ2".
- HLA_A1-B8-DR3-DQ2 haplotype "B8::DR3".
- HLA_A1-B8-DR3-DQ2 haplotype "HLA A1-B8-DR3-DQ2".
- HLA_A1-B8-DR3-DQ2 hasPhotoCollection HLA_A1-B8-DR3-DQ2.
- HLA_A1-B8-DR3-DQ2 imageSource "HLA region on chromosome 6".
- HLA_A1-B8-DR3-DQ2 init7query "True".
- HLA_A1-B8-DR3-DQ2 length "1400".
- HLA_A1-B8-DR3-DQ2 length "4700".
- HLA_A1-B8-DR3-DQ2 location "6".
- HLA_A1-B8-DR3-DQ2 loci1name MHC_class_I.
- HLA_A1-B8-DR3-DQ2 loci1name "centomeric Class I region".
- HLA_A1-B8-DR3-DQ2 loci1rows "3".
- HLA_A1-B8-DR3-DQ2 loci3group "3".
- HLA_A1-B8-DR3-DQ2 loci4name HLA-DR.
- HLA_A1-B8-DR3-DQ2 loci4name "Class III".
- HLA_A1-B8-DR3-DQ2 loci4name "RCCX HVR,".
- HLA_A1-B8-DR3-DQ2 loci4rows "2".
- HLA_A1-B8-DR3-DQ2 loci4rows "5".
- HLA_A1-B8-DR3-DQ2 loci6name HLA-DQ.
- HLA_A1-B8-DR3-DQ2 loci6rows "2".
- HLA_A1-B8-DR3-DQ2 loci9name "DR Loci".
- HLA_A1-B8-DR3-DQ2 loci9rows "2".
- HLA_A1-B8-DR3-DQ2 numloci "-".
- HLA_A1-B8-DR3-DQ2 numloci "311".
- HLA_A1-B8-DR3-DQ2 othertype "Isoform".
- HLA_A1-B8-DR3-DQ2 othertype "Serotype".
- HLA_A1-B8-DR3-DQ2 placement "right".
- HLA_A1-B8-DR3-DQ2 popmax "Western Ireland".
- HLA_A1-B8-DR3-DQ2 type10var "DR3".
- HLA_A1-B8-DR3-DQ2 type1var HLA-A1.
- HLA_A1-B8-DR3-DQ2 type1var "B8".
- HLA_A1-B8-DR3-DQ2 type2var HLA-Cw7.
- HLA_A1-B8-DR3-DQ2 type2var "MICA5.1".
- HLA_A1-B8-DR3-DQ2 type3var HLA-B8.
- HLA_A1-B8-DR3-DQ2 type3var "MICB24".
- HLA_A1-B8-DR3-DQ2 type4var HLA-DR3.
- HLA_A1-B8-DR3-DQ2 type4var "-".
- HLA_A1-B8-DR3-DQ2 type5var HLA-DR52.
- HLA_A1-B8-DR3-DQ2 type5var "-".
- HLA_A1-B8-DR3-DQ2 type6var "C4AQ0".
- HLA_A1-B8-DR3-DQ2 type7var HLA-DQ2.
- HLA_A1-B8-DR3-DQ2 type7var "C4BS".
- HLA_A1-B8-DR3-DQ2 type9var "DR52".
- HLA_A1-B8-DR3-DQ2 subject Category:Human_MHC_haplogroups.
- HLA_A1-B8-DR3-DQ2 subject Category:Human_MHC_mediated_diseases.
- HLA_A1-B8-DR3-DQ2 subject Category:Human_multigene_haplotypes.
- HLA_A1-B8-DR3-DQ2 comment "HLA A1-B8-DR3-DQ2 haplotype (Also: AH8.1, COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype) is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6 (not to be confused with the HLA-DQ heterodimer DQ8.1).".
- HLA_A1-B8-DR3-DQ2 label "HLA A1-B8-DR3-DQ2".
- HLA_A1-B8-DR3-DQ2 sameAs m.04gtqvg.
- HLA_A1-B8-DR3-DQ2 sameAs Q5630199.