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- HLA_DR3-DQ2 abstract "HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype.Certain HLA DR and DQ genes have known involvementin autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored.The frequency of both diseases changes with respect to both the environment (diet) and the frequency of the DR3-DQ2. With coeliac disease risk is increased with the consumption of Triticeae glutens, and this also increases risk in juvenile diabetes whereas other cereals also appear to play a role. More importantly the risk of disease is greatest in homozygotes and linear increases in haplotype resulting in several fold increases of disease risk. This increased risk is most prominent in a rare cancer, enteropathy associated T-cell lymphoma. HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland).".
- HLA_DR3-DQ2 thumbnail HLA-mini.png?width=300.
- HLA_DR3-DQ2 wikiPageExternalLink celiac.
- HLA_DR3-DQ2 wikiPageExternalLink searchAllelePart3-1.asp?Population=Vietnam%20HoaBinh%20Muong.
- HLA_DR3-DQ2 wikiPageExternalLink www.celiac.org.
- HLA_DR3-DQ2 wikiPageExternalLink www.celiacawareness.org.
- HLA_DR3-DQ2 wikiPageExternalLink www.celiaccenter.org.
- HLA_DR3-DQ2 wikiPageExternalLink www.childrenwithdiabetes.com.
- HLA_DR3-DQ2 wikiPageExternalLink www.coeliac.co.uk.
- HLA_DR3-DQ2 wikiPageExternalLink type-1-diabetes.jsp.
- HLA_DR3-DQ2 wikiPageExternalLink get_allele.cgi?DRA*0102.
- HLA_DR3-DQ2 wikiPageID "7522353".
- HLA_DR3-DQ2 wikiPageRevisionID "595364706".
- HLA_DR3-DQ2 alias "HLA DRB1*0301:DQA1*0501:DQB1*0201".
- HLA_DR3-DQ2 chromosome "6".
- HLA_DR3-DQ2 disease Coeliac_disease.
- HLA_DR3-DQ2 disease Diabetes_mellitus_type_1.
- HLA_DR3-DQ2 disease Sarcoidosis.
- HLA_DR3-DQ2 freqmax "22.0".
- HLA_DR3-DQ2 gene1name HLA-DRA.
- HLA_DR3-DQ2 gene1var "*0101".
- HLA_DR3-DQ2 gene2name HLA-DRB1.
- HLA_DR3-DQ2 gene3name HLA-DRB3_(gene).
- HLA_DR3-DQ2 gene4name Major_histocompatibility_complex,_class_II,_DQ_alpha_1.
- HLA_DR3-DQ2 gene5name HLA-DQB1.
- HLA_DR3-DQ2 haplotype DQ2.
- HLA_DR3-DQ2 haplotype "DR3-DQ2".
- HLA_DR3-DQ2 haplotype "HLA DR3-DQ2".
- HLA_DR3-DQ2 hasPhotoCollection HLA_DR3-DQ2.
- HLA_DR3-DQ2 imageSource "HLA region on chromosome 6".
- HLA_DR3-DQ2 length "300".
- HLA_DR3-DQ2 location "6".
- HLA_DR3-DQ2 loci1name HLA-DR.
- HLA_DR3-DQ2 loci1rows "3".
- HLA_DR3-DQ2 loci2name HLA-DR.
- HLA_DR3-DQ2 loci4name HLA-DQ.
- HLA_DR3-DQ2 loci4rows "2".
- HLA_DR3-DQ2 numloci "5".
- HLA_DR3-DQ2 othertype "Serotype".
- HLA_DR3-DQ2 popmax Sardinia.
- HLA_DR3-DQ2 type2var HLA-DR3.
- HLA_DR3-DQ2 type3var HLA-DR52.
- HLA_DR3-DQ2 type5var HLA-DQ2.
- HLA_DR3-DQ2 subject Category:HLA-DQ_haplotypes.
- HLA_DR3-DQ2 subject Category:HLA-DR_haplotypes.
- HLA_DR3-DQ2 subject Category:Human_MHC_haplogroups.
- HLA_DR3-DQ2 subject Category:Human_MHC_mediated_diseases.
- HLA_DR3-DQ2 comment "HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype.Certain HLA DR and DQ genes have known involvementin autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes.".
- HLA_DR3-DQ2 label "HLA DR3-DQ2".
- HLA_DR3-DQ2 sameAs m.026482n.
- HLA_DR3-DQ2 sameAs Q15996533.
- HLA_DR3-DQ2 sameAs Q15996533.
- HLA_DR3-DQ2 wasDerivedFrom HLA_DR3-DQ2?oldid=595364706.
- HLA_DR3-DQ2 depiction HLA-mini.png.
- HLA_DR3-DQ2 isPrimaryTopicOf HLA_DR3-DQ2.