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- HMG-CoA_reductase abstract "HMG-CoA reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGCR) is the rate-controlling enzyme (EC 1.1.1.88& EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. This enzyme is thus the target of the widely available cholesterol-lowering drugs known collectively as the statins. HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol. More recent evidence shows it to contain eight transmembrane domains.The enzyme commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme, whereas 1.1.1.88 links to an NADH-dependent enzyme.In humans, the gene for HMG-CoA reductase is located on the long arm of the fifth chromosome (5q13.3-14). Related enzymes having the same function are also present in other animals, plants and bacteria.".
- HMG-CoA_reductase entrezgene "3156".
- HMG-CoA_reductase thumbnail Mevalonate_pathway.svg?width=300.
- HMG-CoA_reductase wikiPageExternalLink NEW-IMAGE?type=PATHWAY&object=PWY-922.
- HMG-CoA_reductase wikiPageExternalLink cholesterol.htm.
- HMG-CoA_reductase wikiPageID "864596".
- HMG-CoA_reductase wikiPageRevisionID "604072321".
- HMG-CoA_reductase casNumber "37250".
- HMG-CoA_reductase ecNumber "1.1".
- HMG-CoA_reductase goCode "42282".
- HMG-CoA_reductase goCode "4420".
- HMG-CoA_reductase hasPhotoCollection HMG-CoA_reductase.
- HMG-CoA_reductase iubmbEcNumber "1".
- HMG-CoA_reductase name "hydroxymethylglutaryl-CoA reductase".
- HMG-CoA_reductase requireManualInspection "yes".
- HMG-CoA_reductase updateCitations "yes".
- HMG-CoA_reductase updatePage "yes".
- HMG-CoA_reductase updateProteinBox "yes".
- HMG-CoA_reductase updateSummary "no".
- HMG-CoA_reductase subject Category:EC_1.1.1.
- HMG-CoA_reductase type Biomolecule.
- HMG-CoA_reductase type Protein.
- HMG-CoA_reductase type ProteinMolecule.
- HMG-CoA_reductase type BiologicalObject.
- HMG-CoA_reductase comment "HMG-CoA reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGCR) is the rate-controlling enzyme (EC 1.1.1.88& EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol.".
- HMG-CoA_reductase label "3-гидрокси-3-метилглютарил-кофермент А редуктаза".
- HMG-CoA_reductase label "HMG-CoA reductase".
- HMG-CoA_reductase label "HMG-CoA redutase".
- HMG-CoA_reductase label "HMG-CoA-Reduktase".
- HMG-CoA_reductase label "HMG-CoAレダクターゼ".
- HMG-CoA_reductase label "Hydroxyméthylglutaryl-CoA réductase".
- HMG-CoA_reductase label "Idrossimetilglutaril-CoA reduttasi".
- HMG-CoA_reductase label "Reduktaza HMG-CoA".
- HMG-CoA_reductase label "إتش أم جي-كو أيه ريدوكتاز".
- HMG-CoA_reductase label "羟甲基戊二酸单酰辅酶A还原酶".
- HMG-CoA_reductase sameAs HMG-CoA-Reduktase.
- HMG-CoA_reductase sameAs Hydroxyméthylglutaryl-CoA_réductase.
- HMG-CoA_reductase sameAs Idrossimetilglutaril-CoA_reduttasi.
- HMG-CoA_reductase sameAs HMG-CoAレダクターゼ.
- HMG-CoA_reductase sameAs Reduktaza_HMG-CoA.
- HMG-CoA_reductase sameAs HMG-CoA_redutase.
- HMG-CoA_reductase sameAs m.03jm8v.
- HMG-CoA_reductase sameAs Q415607.
- HMG-CoA_reductase sameAs Q415607.
- HMG-CoA_reductase sameAs HMGCR.
- HMG-CoA_reductase sameAs 631.
- HMG-CoA_reductase wasDerivedFrom HMG-CoA_reductase?oldid=604072321.
- HMG-CoA_reductase depiction Mevalonate_pathway.svg.
- HMG-CoA_reductase isPrimaryTopicOf HMG-CoA_reductase.