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- Half_sphere_exposure abstract "Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by Hamelryck (2005).Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to theCβ-Cα vector. This simple division of the CN sphere results intwo strikingly different measures, HSE-up and HSE-down. HSE-up is defined as the number of Cα atoms in theupper half (containing the pseudo-Cβ atom) and analogously HSE-down is defined as the number of Cα atomsin the opposite sphere.If only Cα atoms are available (as is the case for many simplified representations of protein structure), a related measure, called HSEα, can be used. HSEα uses a pseudo-Cβ instead of the real Cβ atom for itscalculation. The position of this pseudo-Cβ atom (pCβ) is derived from the positions of precedingCα−1 and the following Cα+1. The Cα-pCβ vector is calculated by adding theCα−1-Cα0 and Cα+1-Cα0 vectors. HSE is used in predicting discontinuous B-cell epitopes. Recently Song et al. have developed an online webserver termed HSEpred to predict half-sphere exposure from protein primary sequences. HSEpred server can achieve the correlation coefficients of 0.72 and 0.68 between the predicted and observed HSE-up and HSE-down measures, respectively, when evaluated on a well-prepared non-homologous protein structure dataset. Moreover, residue contact number (CN) can also be accurately predicted by HSEpred webserver using the summation of the predicted HSE-up and HSE-down values, which has further enlarged the application of this new solvent exposure measure.".
- Half_sphere_exposure thumbnail HSECa.png?width=300.
- Half_sphere_exposure wikiPageID "7174276".
- Half_sphere_exposure wikiPageRevisionID "567077126".
- Half_sphere_exposure hasPhotoCollection Half_sphere_exposure.
- Half_sphere_exposure subject Category:Amino_acids.
- Half_sphere_exposure subject Category:Nitrogen_metabolism.
- Half_sphere_exposure subject Category:Protein_structure.
- Half_sphere_exposure subject Category:Solvent_accessibility.
- Half_sphere_exposure subject Category:Solvent_exposure_measure.
- Half_sphere_exposure type Abstraction100002137.
- Half_sphere_exposure type AminoAcid114601829.
- Half_sphere_exposure type AminoAcids.
- Half_sphere_exposure type Chemical114806838.
- Half_sphere_exposure type Compound114818238.
- Half_sphere_exposure type Material114580897.
- Half_sphere_exposure type Matter100020827.
- Half_sphere_exposure type OrganicCompound114727670.
- Half_sphere_exposure type Part113809207.
- Half_sphere_exposure type PhysicalEntity100001930.
- Half_sphere_exposure type Relation100031921.
- Half_sphere_exposure type Substance100019613.
- Half_sphere_exposure comment "Half Sphere Exposure (HSE) is a protein solvent exposure measure that was first introduced by Hamelryck (2005).Like all solvent exposure measures it measures how buried amino acid residues are in a protein. It is found by counting the number of amino acid neighbors within two half spheres of chosen radius around the amino acid. The calculation of HSE is found by dividing a contact number (CN) sphere in two halves by the plane perpendicular to theCβ-Cα vector.".
- Half_sphere_exposure label "Half sphere exposure".
- Half_sphere_exposure sameAs m.025v4ly.
- Half_sphere_exposure sameAs Q5641820.
- Half_sphere_exposure sameAs Q5641820.
- Half_sphere_exposure sameAs Half_sphere_exposure.
- Half_sphere_exposure wasDerivedFrom Half_sphere_exposure?oldid=567077126.
- Half_sphere_exposure depiction HSECa.png.
- Half_sphere_exposure isPrimaryTopicOf Half_sphere_exposure.