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- Halofuginone abstract "Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which involved in normal immune function. Halofuginone therefore has potential for the treatment of autoimmune disorders.Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.".
- Halofuginone atcPrefix "P51".
- Halofuginone atcSuffix "AX08".
- Halofuginone casNumber "55837-20-2".
- Halofuginone fdaUniiCode "L31MM1385E".
- Halofuginone iupacName "7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4-quinazolinone".
- Halofuginone pubchem "400772".
- Halofuginone thumbnail Halofuginone2DACS.svg?width=300.
- Halofuginone wikiPageID "21103821".
- Halofuginone wikiPageRevisionID "598367650".
- Halofuginone atcPrefix "P51".
- Halofuginone atcSuffix "AX08".
- Halofuginone atcvet "yes".
- Halofuginone br "1".
- Halofuginone c "16".
- Halofuginone casNumber "55837".
- Halofuginone chembl "1199540".
- Halofuginone chemspiderid "355164".
- Halofuginone cl "1".
- Halofuginone h "17".
- Halofuginone hasPhotoCollection Halofuginone.
- Halofuginone inchi "1".
- Halofuginone inchikey "LVASCWIMLIKXLA-LSDHHAIUBL".
- Halofuginone iupacName "7".
- Halofuginone molecularWeight "414.68".
- Halofuginone n "3".
- Halofuginone o "3".
- Halofuginone pubchem "400772".
- Halofuginone smiles "Brc1cc2/N=C\NCCC[C@@H]3NCCC[C@H]3O".
- Halofuginone smiles "O=CC[C@@H]1NCCC[C@H]1O".
- Halofuginone stdinchi "1".
- Halofuginone stdinchikey "LVASCWIMLIKXLA-LSDHHAIUSA-N".
- Halofuginone unii "L31MM1385E".
- Halofuginone verifiedfields "changed".
- Halofuginone verifiedrevid "444144628".
- Halofuginone watchedfields "changed".
- Halofuginone subject Category:Alcohols.
- Halofuginone subject Category:Antiparasitic_agents.
- Halofuginone subject Category:Ketones.
- Halofuginone subject Category:Lactams.
- Halofuginone subject Category:Organobromides.
- Halofuginone subject Category:Organochlorides.
- Halofuginone subject Category:Piperidines.
- Halofuginone subject Category:Quinazolinones.
- Halofuginone type Abstraction100002137.
- Halofuginone type Agent114778436.
- Halofuginone type Alcohol107884567.
- Halofuginone type Alcohols.
- Halofuginone type Beverage107881800.
- Halofuginone type CausalAgent100007347.
- Halofuginone type Chemical114806838.
- Halofuginone type Compound114818238.
- Halofuginone type Drug103247620.
- Halofuginone type DrugOfAbuse103248958.
- Halofuginone type Fluid114939900.
- Halofuginone type Food100021265.
- Halofuginone type Ketone114926294.
- Halofuginone type Ketones.
- Halofuginone type Liquid114940386.
- Halofuginone type Material114580897.
- Halofuginone type Matter100020827.
- Halofuginone type OrganicCompound114727670.
- Halofuginone type Part113809207.
- Halofuginone type PhysicalEntity100001930.
- Halofuginone type Relation100031921.
- Halofuginone type Substance100019613.
- Halofuginone type Substance100020090.
- Halofuginone type Drug.
- Halofuginone type DrugProduct.
- Halofuginone type FunctionalSubstance.
- Halofuginone comment "Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S.".
- Halofuginone label "Halofuginone".
- Halofuginone label "Галофугинон".
- Halofuginone sameAs m.05c1dht.
- Halofuginone sameAs Q4132745.
- Halofuginone sameAs Q4132745.
- Halofuginone sameAs Halofuginone.
- Halofuginone wasDerivedFrom Halofuginone?oldid=598367650.
- Halofuginone depiction Halofuginone2DACS.svg.
- Halofuginone isPrimaryTopicOf Halofuginone.