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- Hemidesmosome abstract "Hemidesmosomes (HD) are very small stud- or rivet-like structures on the inner basal surface of keratinocytes in the epidermis of skin. They are similar in form to desmosomes when visualized by electron microscopy. While desmosomes link two cells together, hemidesmosomes attach one cell to the extracellular matrix. Rather than using desmogleins, hemidesmosomes use desmopenetrin cell adhesion proteins. Hemidesmosomes are asymmetrical and are found in epithelial cells connecting the basal face of the cell to basal lamina.The HD comprises two rivet-like plaques (the inner and outer plaques). Together with the anchoring fibrils and anchoring filaments, these are collectively termed the HD-stable adhesion complex or HD-anchoring filament complex. Together, the HD-anchoring filament complex forms a continuous structural link between the basal keratinocyte keratin intermediate filaments and the underlying basement membrane zone (BMZ) and dermal components. Over the past decade, these structures have been shown to comprise a variety of some 10 or more molecular components. An example configuration of a hemidesmosome might consist of cytosolic keratin, non-covalently bonded to a cytosolic plectin plaque, which is bonded to a single-pass transmembrane adhesion molecule such as the α6β4 integrin. The integrin might then attach to one of many multi-adhesive proteins such as laminin, resident within the extracellular matrix, thereby forming one of many potential adhesions between cell and matrix.Electron microscopic analysis of the epidermal basement membrane zone (BMZ) reveals that it comprises a narrow and sometimes folded interface between the basal keratinocytes and the dermis. At high power, several complex structures are observed within the epidermal BMZ. The epidermal BMZ shows small (< 0.5 micrometers), regularly spaced electron dense structures which are the hemidesmosomes. Thin, extracellular, electron-dense lines, parallel to the plasma membrane, subjacent to the outer plaque are visible in one third of HDs and are termed sub-basal dense plates (SBDPs).Anchoring filaments traverse the lamina lucida space and appear to insert into the electron dense zone, the lamina densa. Beneath the lamina densa, loop-structured, cross-banded anchoring fibrils extend more than 300 nm beneath the basement membrane within the papillary dermis. The length of these loops may enable them to link or encircle dermal collagen fibers or other components such as those of the elastic microfibril network.".
- Hemidesmosome thumbnail Ultrastructure_of_tracheal_hemidesmosomes_in_mice.JPEG?width=300.
- Hemidesmosome wikiPageID "1104424".
- Hemidesmosome wikiPageRevisionID "542797603".
- Hemidesmosome caption "Ultrastructure of tracheal hemidesmosomes in mice. In a normal mouse there are well-defined, organized hemidesmosomes with darkened areas in the lamina densa abutting the hemidesmosome . In contrast, hemidesmosomes in Lamc2 -/- tracheas are less organized, the intracellular component is more diffuse, and the lamina densa directly below the hemidesmosomal areas lacks the electron density seen in the littermate control . From Nguyen et al., 2006.".
- Hemidesmosome hasPhotoCollection Hemidesmosome.
- Hemidesmosome latin "hemidesmosoma".
- Hemidesmosome subject Category:Cell_anatomy.
- Hemidesmosome subject Category:Skin_anatomy.
- Hemidesmosome type Abstraction100002137.
- Hemidesmosome type Anatomy106057539.
- Hemidesmosome type Biology106037666.
- Hemidesmosome type Cognition100023271.
- Hemidesmosome type Content105809192.
- Hemidesmosome type Discipline105996646.
- Hemidesmosome type KnowledgeDomain105999266.
- Hemidesmosome type LifeScience106037298.
- Hemidesmosome type Morphology106078327.
- Hemidesmosome type NaturalScience106000400.
- Hemidesmosome type PsychologicalFeature100023100.
- Hemidesmosome type Science105999797.
- Hemidesmosome type AnatomicalStructure.
- Hemidesmosome type BiologicalObject.
- Hemidesmosome comment "Hemidesmosomes (HD) are very small stud- or rivet-like structures on the inner basal surface of keratinocytes in the epidermis of skin. They are similar in form to desmosomes when visualized by electron microscopy. While desmosomes link two cells together, hemidesmosomes attach one cell to the extracellular matrix. Rather than using desmogleins, hemidesmosomes use desmopenetrin cell adhesion proteins.".
- Hemidesmosome label "Emidesmosoma".
- Hemidesmosome label "Hemidesmosom".
- Hemidesmosome label "Hemidesmosome".
- Hemidesmosome label "Hemidesmossomo".
- Hemidesmosome label "Hémidesmosome".
- Hemidesmosome label "Półdesmosomy".
- Hemidesmosome label "Гемидесмосома".
- Hemidesmosome label "半接着斑".
- Hemidesmosome sameAs Hemidesmozom.
- Hemidesmosome sameAs Hemidesmosom.
- Hemidesmosome sameAs Hémidesmosome.
- Hemidesmosome sameAs Emidesmosoma.
- Hemidesmosome sameAs 半接着斑.
- Hemidesmosome sameAs Półdesmosomy.
- Hemidesmosome sameAs Hemidesmossomo.
- Hemidesmosome sameAs m.046b5r.
- Hemidesmosome sameAs Q1604780.
- Hemidesmosome sameAs Q1604780.
- Hemidesmosome sameAs Hemidesmosome.
- Hemidesmosome wasDerivedFrom Hemidesmosome?oldid=542797603.
- Hemidesmosome depiction Ultrastructure_of_tracheal_hemidesmosomes_in_mice.JPEG.
- Hemidesmosome isPrimaryTopicOf Hemidesmosome.