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- Hemopexin_family abstract "The hemopexin family is a family of evolutionarily related proteins. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).Hemopexin (EC 3.2.1.35) is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin, a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).".
- Hemopexin_family symbol "Hemopexin".
- Hemopexin_family wikiPageID "28960981".
- Hemopexin_family wikiPageRevisionID "591623257".
- Hemopexin_family hasPhotoCollection Hemopexin_family.
- Hemopexin_family interpro "IPR000585".
- Hemopexin_family name "Hemopexin".
- Hemopexin_family pdb ":328-372 B:328-372 :334-377 A:334-377 B:520-563 A:520-563 :520-563 :520-563 B:567-608 A:567-608 :306-349 A:306-349 A:306-349".
- Hemopexin_family pfam "PF00045".
- Hemopexin_family prosite "PDOC00023".
- Hemopexin_family scop "1".
- Hemopexin_family smart "HX".
- Hemopexin_family symbol "Hemopexin".
- Hemopexin_family subject Category:Single-pass_transmembrane_proteins.
- Hemopexin_family type Abstraction100002137.
- Hemopexin_family type Chemical114806838.
- Hemopexin_family type Compound114818238.
- Hemopexin_family type Macromolecule114944888.
- Hemopexin_family type Material114580897.
- Hemopexin_family type Matter100020827.
- Hemopexin_family type Molecule114682133.
- Hemopexin_family type OrganicCompound114727670.
- Hemopexin_family type Part113809207.
- Hemopexin_family type PhysicalEntity100001930.
- Hemopexin_family type Protein114728724.
- Hemopexin_family type Relation100031921.
- Hemopexin_family type Single-passTransmembraneProteins.
- Hemopexin_family type Substance100019613.
- Hemopexin_family type Thing100002452.
- Hemopexin_family type Unit109465459.
- Hemopexin_family type Biomolecule.
- Hemopexin_family type Protein.
- Hemopexin_family type BiologicalObject.
- Hemopexin_family comment "The hemopexin family is a family of evolutionarily related proteins. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).Hemopexin (EC 3.2.1.35) is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Hemopexin prevents haem-mediated oxidative stress.".
- Hemopexin_family label "Hemopexin family".
- Hemopexin_family sameAs m.0dgrf21.
- Hemopexin_family sameAs Q5712519.
- Hemopexin_family sameAs Q5712519.
- Hemopexin_family sameAs Hemopexin_family.
- Hemopexin_family wasDerivedFrom Hemopexin_family?oldid=591623257.
- Hemopexin_family isPrimaryTopicOf Hemopexin_family.