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- High_endothelial_venules abstract "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules. HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV).In humans, HEVs are found in all secondary lymphoid organs (with the exception of spleen, where blood exits through open arterioles and enters the red pulp), including hundreds of lymph nodes dispersed in the body, tonsils and adenoids in the pharynx, Peyer's patches (PIs) in the small intestine, appendix, and small aggregates of lymphoid tissue in the stomach and large intestine. In contrast to the endothelial cells from other vessels, the high endothelial cells of HEVs have a distinctive appearance, consisting of a cuboidal morphology and with various receptors to interact with leukocytes (express specialized ligands for lymphocytes and are able to support high levels of lymphocyte extravasation). HEVs enable naïve lymphocytes to move in and out of the lymph nodes from the circulatory system. HEV cells express addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing the endothelium.The endothelial cells of HEVs have a 'plump' appearance different from the flat morphology of endothelial cells that line other vessels, and are therefore called high endothelial cells by reference to their thickness. Another characteristic of HEVs, revealed by light-microscopic examination, is the presence of a large number of lymphocytes within their walls. This illustrates the function of HEVs in lymphocyte recruitment, and explains why these vessels were implicated in lymphocyte traffic from the time of their initial description.".
- High_endothelial_venules wikiPageID "7026804".
- High_endothelial_venules wikiPageRevisionID "605264388".
- High_endothelial_venules hasPhotoCollection High_endothelial_venules.
- High_endothelial_venules subject Category:Angiology.
- High_endothelial_venules subject Category:Tissues.
- High_endothelial_venules type BodyPart105220461.
- High_endothelial_venules type Part109385911.
- High_endothelial_venules type PhysicalEntity100001930.
- High_endothelial_venules type Thing100002452.
- High_endothelial_venules type Tissue105267345.
- High_endothelial_venules type Tissues.
- High_endothelial_venules comment "High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules.".
- High_endothelial_venules label "High endothelial venules".
- High_endothelial_venules label "Hochendotheliale Venole".
- High_endothelial_venules label "Veinule à endothélium épais".
- High_endothelial_venules label "Venule ad endotelio alto".
- High_endothelial_venules sameAs Hochendotheliale_Venole.
- High_endothelial_venules sameAs Veinule_à_endothélium_épais.
- High_endothelial_venules sameAs Venule_ad_endotelio_alto.
- High_endothelial_venules sameAs m.0h0z6g.
- High_endothelial_venules sameAs Q637997.
- High_endothelial_venules sameAs Q637997.
- High_endothelial_venules sameAs High_endothelial_venules.
- High_endothelial_venules wasDerivedFrom High_endothelial_venules?oldid=605264388.
- High_endothelial_venules isPrimaryTopicOf High_endothelial_venules.