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- Hypersegmented_neutrophil abstract "A hypersegmented neutrophil is a clinical laboratory finding. It is visualized by drawing blood from a patient and viewing the blood smeared on a slide under a microscope. Normally, the number of segments in the nucleus of a neutrophil increases as it matures and ages, after being released into the blood from the bone marrow. Whereas normal neutrophils only contain three or four nuclear lobes (the "segments"), hypersegmented neutrophils contain six or more lobes.Hypersegmented neutrophils have classically been thought to be pathognomonic of the class of anemias called megaloblastic anemias (anemias caused by failure of bone marrow blood-forming cells to make DNA, often caused by vitamin B12 or folate deficiencies, or DNA-replication poisons). However, in seeming contradiction to this, several studies have strongly associated neutrophil hypersegmentation with iron deficiency anemia. In one study 81% of children with iron deficiency had hypersegmented neutrophils, vs. 9% of controls. The mechanism for hypersegmentation in iron deficiency is not yet clear, but has been suggested to be concurrent iron and vitamin deficiency.One of the earliest, notable changes in the peripheral blood in megaloblastic processes is the appearance of hypersegmented neutrophils. Because of the short life-span of neutrophils, these abnormal hypersegmented neutrophils characteristically appear even before the onset of anemia in megaloblastic processes. Such neutrophils are less often seen in the other classes of anemia, which together are far more common than megaloblastic types of anemia. However, as noted, the use of hypersegmented neutrophils to diagnose type of anemia is limited by the fact that different types of nutrient deficiency anemia may coexist.Note that pernicious anemia is a type of megaloblastic anemia, and as such, is expected to show hypersegmented neutrophils.".
- Hypersegmented_neutrophil thumbnail Hypersegmented_neutrophil.png?width=300.
- Hypersegmented_neutrophil wikiPageID "17756980".
- Hypersegmented_neutrophil wikiPageRevisionID "530232059".
- Hypersegmented_neutrophil hasPhotoCollection Hypersegmented_neutrophil.
- Hypersegmented_neutrophil subject Category:Anatomical_pathology.
- Hypersegmented_neutrophil subject Category:Cell_biology.
- Hypersegmented_neutrophil subject Category:Granulocytes.
- Hypersegmented_neutrophil subject Category:Hematopathology.
- Hypersegmented_neutrophil subject Category:Histology.
- Hypersegmented_neutrophil subject Category:Histopathology.
- Hypersegmented_neutrophil subject Category:Human_cells.
- Hypersegmented_neutrophil subject Category:Monocyte_and_granulocyte_disorders.
- Hypersegmented_neutrophil subject Category:Phagocytes.
- Hypersegmented_neutrophil type BloodCell105449268.
- Hypersegmented_neutrophil type Cell100006484.
- Hypersegmented_neutrophil type FreePhagocyte105451265.
- Hypersegmented_neutrophil type Granulocyte105453145.
- Hypersegmented_neutrophil type Granulocytes.
- Hypersegmented_neutrophil type Leukocyte105449959.
- Hypersegmented_neutrophil type LivingThing100004258.
- Hypersegmented_neutrophil type Object100002684.
- Hypersegmented_neutrophil type Phagocyte105450888.
- Hypersegmented_neutrophil type Phagocytes.
- Hypersegmented_neutrophil type PhysicalEntity100001930.
- Hypersegmented_neutrophil type SomaticCell105430628.
- Hypersegmented_neutrophil type Whole100003553.
- Hypersegmented_neutrophil comment "A hypersegmented neutrophil is a clinical laboratory finding. It is visualized by drawing blood from a patient and viewing the blood smeared on a slide under a microscope. Normally, the number of segments in the nucleus of a neutrophil increases as it matures and ages, after being released into the blood from the bone marrow.".
- Hypersegmented_neutrophil label "Hypersegmented neutrophil".
- Hypersegmented_neutrophil sameAs m.047bf6g.
- Hypersegmented_neutrophil sameAs Q5958563.
- Hypersegmented_neutrophil sameAs Q5958563.
- Hypersegmented_neutrophil sameAs Hypersegmented_neutrophil.
- Hypersegmented_neutrophil wasDerivedFrom Hypersegmented_neutrophil?oldid=530232059.
- Hypersegmented_neutrophil depiction Hypersegmented_neutrophil.png.
- Hypersegmented_neutrophil isPrimaryTopicOf Hypersegmented_neutrophil.