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- IκB_kinase abstract "The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. IKK specifically, phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.".
- IκB_kinase wikiPageID "13551967".
- IκB_kinase wikiPageRevisionID "591872265".
- IκB_kinase altsymbols "IKK-alpha, IKK1, TCF16".
- IκB_kinase altsymbols "IKK-beta, IKK2".
- IκB_kinase altsymbols "IKK-gamma, NEMO, IP2, IP1".
- IκB_kinase arm "p".
- IκB_kinase arm "q".
- IκB_kinase band "11.2".
- IκB_kinase band "24".
- IκB_kinase band "28".
- IκB_kinase casNumber "159606".
- IκB_kinase chromosome "10".
- IκB_kinase chromosome "8".
- IκB_kinase chromosome "X".
- IκB_kinase ecNumber "2.7".
- IκB_kinase ecnumber "2.7".
- IκB_kinase entrezgene "1147".
- IκB_kinase entrezgene "3551".
- IκB_kinase entrezgene "8517".
- IκB_kinase goCode "8384".
- IκB_kinase hgncid "1974".
- IκB_kinase hgncid "5960".
- IκB_kinase hgncid "5961".
- IκB_kinase iubmbEcNumber "2".
- IκB_kinase locussupplementarydata "-q25".
- IκB_kinase name CHUK.
- IκB_kinase name IKBKG.
- IκB_kinase name IKK2.
- IκB_kinase name "IkappaB kinase".
- IκB_kinase omim "300248".
- IκB_kinase omim "600664".
- IκB_kinase omim "603258".
- IκB_kinase refseq "NM_001278".
- IκB_kinase refseq "NM_001556".
- IκB_kinase refseq "NM_003639".
- IκB_kinase symbol "CHUK".
- IκB_kinase symbol "IKBKB".
- IκB_kinase symbol "IKBKG".
- IκB_kinase uniprot "O14920".
- IκB_kinase uniprot "O15111".
- IκB_kinase uniprot "Q9Y6K9".
- IκB_kinase subject Category:EC_2.7.11.
- IκB_kinase subject Category:Enzymes_of_unknown_structure.
- IκB_kinase subject Category:Protein_complexes.
- IκB_kinase type Biomolecule.
- IκB_kinase type Enzyme.
- IκB_kinase type BiologicalObject.
- IκB_kinase comment "The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. IKK specifically, phosphorylates the inhibitory IκBα protein.".
- IκB_kinase label "IκB kinase".
- IκB_kinase sameAs I%CE%BAB_kinase.
- IκB_kinase sameAs Q6103519.
- IκB_kinase sameAs Q6103519.
- IκB_kinase wasDerivedFrom IκB_kinase?oldid=591872265.