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- ICI-118,551 abstract "ICI-118,551 is a selective beta-2 (β2) adrenergic receptor antagonist. ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008. ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known. When dissolved in saline, the compound crosses the blood–brain barrier. Common systemic doses used in rodent research are .5 or 1 mg/kg although efficacy has been demonstrated at doses as low as .0001 mg/kg in rhesus monkeys. Doses up to 20 mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to at least 2.5 mg/mL.".
- ICI-118,551 iupacName "3-(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol".
- ICI-118,551 thumbnail ICI_118551.svg?width=300.
- ICI-118,551 wikiPageID "18850804".
- ICI-118,551 wikiPageRevisionID "591763225".
- ICI-118,551 hasPhotoCollection ICI-118,551.
- ICI-118,551 imagefile "ICI 118551.svg".
- ICI-118,551 iupacname "3".
- ICI-118,551 verifiedfields "changed".
- ICI-118,551 verifiedrevid "424696718".
- ICI-118,551 subject Category:Alcohols.
- ICI-118,551 subject Category:Beta_blockers.
- ICI-118,551 subject Category:Indanes.
- ICI-118,551 subject Category:Phenol_ethers.
- ICI-118,551 type ChemicalCompound.
- ICI-118,551 type ChemicalSubstance.
- ICI-118,551 type ChemicalSubstanceType.
- ICI-118,551 type ChemicalObject.
- ICI-118,551 type Thing.
- ICI-118,551 comment "ICI-118,551 is a selective beta-2 (β2) adrenergic receptor antagonist. ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008.".
- ICI-118,551 label "ICI 118551".
- ICI-118,551 label "ICI-118,551".
- ICI-118,551 sameAs ICI_118551.
- ICI-118,551 sameAs m.04gprjj.
- ICI-118,551 sameAs Q6571514.
- ICI-118,551 sameAs Q6571514.
- ICI-118,551 wasDerivedFrom ICI-118,551?oldid=591763225.
- ICI-118,551 depiction ICI_118551.svg.
- ICI-118,551 isPrimaryTopicOf ICI-118,551.