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- IMD_domain abstract "In molecular biology, the IMD domain (IRSp53 and MIM (missing in metastases) homology Domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 (Rho-family GTPases) and is SH3-independent. The IRSp53/MIM family is a novel F-actin bundling protein family that includes invertebrate relatives: Vertebrate MIM (missing in metastasis) (MTSS1), an actin-binding scaffold protein that may be involved in cancer metastasis. Vertebrate ABBA-1 (MTSS1L), a MIM-related protein. Vertebrate brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1-associated protein 2) or insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2/WASF2) to induce lamellipodia or Cdc42 with Mena to induce filopodia. Vertebrate brain-specific angiogenesis nhibitor 1-associated protein 2-like proteins 1 and 2 (BAI1-associated protein 2-like proteins 1 and 2, BAIAP2L1 and BAIAP2L2). Drosophila melanogaster (Fruit fly) CG32082-PA. Caenorhabditis elegans M04F3.5 protein. The vertebrate IRSp53/MIM family is divided into two major groups: the IRSp53 subfamily and the MIM/ABBA subfamily. The putative invertebrate homologues are positioned between them. The IRSp53 subfamily members contain an SH3 domain, and the MIM/ABBA subfamily proteins contain a WH2 (WASP-homology 2) domain. The vertebrate SH3-containing subfamily is further divided into three groups according to the presence or absence of the WWB and the half-CRIB motif. The IMD domain can bind to and bundle actin filaments, bind to membranes and interact with the small GTPase Rac.The IMD domain folds as a coiled coil of three extended alpha-helices and a shorter C-terminal helix. Helix 4 packs tightly against the other three helices, and thus represents an integral part of the domain. The fold of the IMD domain closely resembles that of the BAR (Bin-Amphiphysin-RVS) domain, a functional module serving both as a sensor and inducer of membrane curvature. The WH2 domain performs a scaffolding function.".
- IMD_domain symbol "IMD".
- IMD_domain thumbnail PDB_1wdz_EBI.jpg?width=300.
- IMD_domain wikiPageID "34122040".
- IMD_domain wikiPageRevisionID "591775869".
- IMD_domain caption "crystal structure of rcb domain of irsp53".
- IMD_domain hasPhotoCollection IMD_domain.
- IMD_domain interpro "IPR013606".
- IMD_domain name "IRSp53/MIM homology domain".
- IMD_domain pfam "PF08397".
- IMD_domain pfamClan "CL0145".
- IMD_domain symbol "IMD".
- IMD_domain subject Category:Protein_families.
- IMD_domain type Abstraction100002137.
- IMD_domain type Family108078020.
- IMD_domain type Group100031264.
- IMD_domain type Organization108008335.
- IMD_domain type ProteinFamilies.
- IMD_domain type SocialGroup107950920.
- IMD_domain type Unit108189659.
- IMD_domain type YagoLegalActor.
- IMD_domain type YagoLegalActorGeo.
- IMD_domain type YagoPermanentlyLocatedEntity.
- IMD_domain type Biomolecule.
- IMD_domain type Protein.
- IMD_domain type BiologicalObject.
- IMD_domain comment "In molecular biology, the IMD domain (IRSp53 and MIM (missing in metastases) homology Domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation.".
- IMD_domain label "IMD domain".
- IMD_domain sameAs m.0hr0ryl.
- IMD_domain sameAs Q5971987.
- IMD_domain sameAs Q5971987.
- IMD_domain sameAs IMD_domain.
- IMD_domain wasDerivedFrom IMD_domain?oldid=591775869.
- IMD_domain depiction PDB_1wdz_EBI.jpg.
- IMD_domain isPrimaryTopicOf IMD_domain.