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- Imidazoleglycerol-phosphate_dehydratase abstract "In enzymology, an imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) is an enzyme that catalyzes the chemical reactionD-erythro-1-(imidazol-4-yl)glycerol 3-phosphate 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2OHence, this enzyme has one substrate, D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate, and two products, 3-(imidazol-4-yl)-2-oxopropyl phosphate and H2O. This reaction is the seventh step in the biosynthesis of histidine in bacteria, fungi and plants.This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-erythro-1-(imidazol-4-yl)glycerol-3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]. Other names in common use include IGP dehydratase, and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase. This enzyme participates in histidine metabolism as it is involved in the 6th step of histidine biosynthesis as part of a nine step cyclical pathway. IGPD is a recognised novel herbicide target as animals do not have an IGPDThere are two isoforms of IGPD; IGPD1 and IGPD2. The different isoforms are highly conserved with only 8 amino acids differing between them. These subtle differences however affect their activity but as yet it is unknown how.In most organisms IGPD is a monofunctional protein of about 22 to 29 kD. In some bacteria such as Escherichia coli, it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain. In E. coli, this is the protein encoded by the hisB gene.".
- Imidazoleglycerol-phosphate_dehydratase ecNumber "4.2.1.19".
- Imidazoleglycerol-phosphate_dehydratase thumbnail PDB_1rhy_EBI.jpg?width=300.
- Imidazoleglycerol-phosphate_dehydratase wikiPageID "14335262".
- Imidazoleglycerol-phosphate_dehydratase wikiPageRevisionID "591776018".
- Imidazoleglycerol-phosphate_dehydratase caption "crystal structure of imidazole glycerol phosphate dehydratase".
- Imidazoleglycerol-phosphate_dehydratase casNumber "9024".
- Imidazoleglycerol-phosphate_dehydratase ecNumber "4.2".
- Imidazoleglycerol-phosphate_dehydratase goCode "4424".
- Imidazoleglycerol-phosphate_dehydratase hasPhotoCollection Imidazoleglycerol-phosphate_dehydratase.
- Imidazoleglycerol-phosphate_dehydratase interpro "IPR000807".
- Imidazoleglycerol-phosphate_dehydratase iubmbEcNumber "4".
- Imidazoleglycerol-phosphate_dehydratase name "Imidazoleglycerol-phosphate dehydratase".
- Imidazoleglycerol-phosphate_dehydratase name "imidazoleglycerol-phosphate dehydratase".
- Imidazoleglycerol-phosphate_dehydratase pfam "PF00475".
- Imidazoleglycerol-phosphate_dehydratase pfamClan "CL0329".
- Imidazoleglycerol-phosphate_dehydratase prosite "PDOC00738".
- Imidazoleglycerol-phosphate_dehydratase scop "1".
- Imidazoleglycerol-phosphate_dehydratase symbol "IGPD".
- Imidazoleglycerol-phosphate_dehydratase subject Category:EC_4.2.1.
- Imidazoleglycerol-phosphate_dehydratase subject Category:Enzymes_of_known_structure.
- Imidazoleglycerol-phosphate_dehydratase type Abstraction100002137.
- Imidazoleglycerol-phosphate_dehydratase type Activator114723079.
- Imidazoleglycerol-phosphate_dehydratase type Catalyst114723628.
- Imidazoleglycerol-phosphate_dehydratase type Chemical114806838.
- Imidazoleglycerol-phosphate_dehydratase type Compound114818238.
- Imidazoleglycerol-phosphate_dehydratase type Enzyme114732946.
- Imidazoleglycerol-phosphate_dehydratase type EnzymesOfKnownStructure.
- Imidazoleglycerol-phosphate_dehydratase type Macromolecule114944888.
- Imidazoleglycerol-phosphate_dehydratase type Material114580897.
- Imidazoleglycerol-phosphate_dehydratase type Matter100020827.
- Imidazoleglycerol-phosphate_dehydratase type Molecule114682133.
- Imidazoleglycerol-phosphate_dehydratase type OrganicCompound114727670.
- Imidazoleglycerol-phosphate_dehydratase type Part113809207.
- Imidazoleglycerol-phosphate_dehydratase type PhysicalEntity100001930.
- Imidazoleglycerol-phosphate_dehydratase type Protein114728724.
- Imidazoleglycerol-phosphate_dehydratase type Relation100031921.
- Imidazoleglycerol-phosphate_dehydratase type Substance100019613.
- Imidazoleglycerol-phosphate_dehydratase type Thing100002452.
- Imidazoleglycerol-phosphate_dehydratase type Unit109465459.
- Imidazoleglycerol-phosphate_dehydratase type Biomolecule.
- Imidazoleglycerol-phosphate_dehydratase type Enzyme.
- Imidazoleglycerol-phosphate_dehydratase type BiologicalObject.
- Imidazoleglycerol-phosphate_dehydratase comment "In enzymology, an imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) is an enzyme that catalyzes the chemical reactionD-erythro-1-(imidazol-4-yl)glycerol 3-phosphate 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2OHence, this enzyme has one substrate, D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate, and two products, 3-(imidazol-4-yl)-2-oxopropyl phosphate and H2O.".
- Imidazoleglycerol-phosphate_dehydratase label "Imidazoleglycerol-phosphate dehydratase".
- Imidazoleglycerol-phosphate_dehydratase sameAs m.03d0wp1.
- Imidazoleglycerol-phosphate_dehydratase sameAs Q13379149.
- Imidazoleglycerol-phosphate_dehydratase sameAs Q13379149.
- Imidazoleglycerol-phosphate_dehydratase sameAs 2905.
- Imidazoleglycerol-phosphate_dehydratase sameAs Imidazoleglycerol-phosphate_dehydratase.
- Imidazoleglycerol-phosphate_dehydratase wasDerivedFrom Imidazoleglycerol-phosphate_dehydratase?oldid=591776018.
- Imidazoleglycerol-phosphate_dehydratase depiction PDB_1rhy_EBI.jpg.
- Imidazoleglycerol-phosphate_dehydratase isPrimaryTopicOf Imidazoleglycerol-phosphate_dehydratase.
- Imidazoleglycerol-phosphate_dehydratase name "imidazoleglycerol-phosphate dehydratase".