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- Inhibitor_cystine_knot abstract "An inhibitor cystine knot (ICK) is a protein structural motif containing three disulfide bridges. Along with the sections of polypeptide between them, two disulfides form a loop through which the third disulfide bond (linking the 3rd and 6th cysteine in the sequence) passes, forming a knot (thus the alternate name knottin). The motif is common in invertebrate toxins such as those from arachnids and molluscs. The motif is also found in some inhibitor proteins found in plants, but the plant and animal motifs are thought to be a product of convergent evolution. The ICK motif is a very stable protein structure which is resistant to heat denaturation and proteolysis.ICK peptide components of venoms target voltage-gated ion channels but members of the family also act as antibacterial and haemolytic agents. Plant ICK proteins are often protease inhibitors. Because of their stability, ICK motifs are being developed as possible therapeutics. The mammalian proteins Agouti signalling peptide and Agouti related peptide are the only know mammalian examples of this motif. Both are neuropeptides involved in cell signalling. The former is responsible for hair (fur) colouration.The motif is similar to the cyclic cystine knot or cyclotide, but lacks the cyclisation of the polypeptide backbone which is present in the latter family. The growth factor cystine knot (GFCK) shares the motif but its topology is such that it is the bond between the first and fourth disulphide which threads through the loop.".
- Inhibitor_cystine_knot thumbnail ICK_topology1.svg?width=300.
- Inhibitor_cystine_knot wikiPageExternalLink knottin.cbs.cnrs.fr.
- Inhibitor_cystine_knot wikiPageExternalLink knots.html%20The%20Cyclotide%20webpages.
- Inhibitor_cystine_knot wikiPageID "41336858".
- Inhibitor_cystine_knot wikiPageRevisionID "596513424".
- Inhibitor_cystine_knot subject Category:Ion_channel_toxins.
- Inhibitor_cystine_knot subject Category:Neurotoxins.
- Inhibitor_cystine_knot subject Category:Protein_folds.
- Inhibitor_cystine_knot subject Category:Protein_structure.
- Inhibitor_cystine_knot comment "An inhibitor cystine knot (ICK) is a protein structural motif containing three disulfide bridges. Along with the sections of polypeptide between them, two disulfides form a loop through which the third disulfide bond (linking the 3rd and 6th cysteine in the sequence) passes, forming a knot (thus the alternate name knottin). The motif is common in invertebrate toxins such as those from arachnids and molluscs.".
- Inhibitor_cystine_knot label "Inhibitor cystine knot".
- Inhibitor_cystine_knot sameAs m.0zmynws.
- Inhibitor_cystine_knot sameAs Q17138737.
- Inhibitor_cystine_knot sameAs Q17138737.
- Inhibitor_cystine_knot wasDerivedFrom Inhibitor_cystine_knot?oldid=596513424.
- Inhibitor_cystine_knot depiction ICK_topology1.svg.
- Inhibitor_cystine_knot isPrimaryTopicOf Inhibitor_cystine_knot.