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- Interleukin_12_subunit_beta abstract "Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (human gene name IL12B) is a subunit of human interleukin 12.This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter gene polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.".
- Interleukin_12_subunit_beta entrezgene "3593".
- Interleukin_12_subunit_beta wikiPageID "14111987".
- Interleukin_12_subunit_beta wikiPageRevisionID "591804028".
- Interleukin_12_subunit_beta requireManualInspection "no".
- Interleukin_12_subunit_beta summaryText "This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis , suggesting a role of this cytokine in the pathogenesis of the disease. The promoter gene polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.".
- Interleukin_12_subunit_beta updateCitations "yes".
- Interleukin_12_subunit_beta updatePage "yes".
- Interleukin_12_subunit_beta updateProteinBox "yes".
- Interleukin_12_subunit_beta updateSummary "no".
- Interleukin_12_subunit_beta subject Category:Cytokines.
- Interleukin_12_subunit_beta subject Category:Human_proteins.
- Interleukin_12_subunit_beta type Biomolecule.
- Interleukin_12_subunit_beta type Protein.
- Interleukin_12_subunit_beta type BiologicalObject.
- Interleukin_12_subunit_beta comment "Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (human gene name IL12B) is a subunit of human interleukin 12.This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities.".
- Interleukin_12_subunit_beta label "Interleukin 12 subunit beta".
- Interleukin_12_subunit_beta sameAs m.03cv010.
- Interleukin_12_subunit_beta sameAs Q17155710.
- Interleukin_12_subunit_beta sameAs Q17155710.
- Interleukin_12_subunit_beta wasDerivedFrom Interleukin_12_subunit_beta?oldid=591804028.
- Interleukin_12_subunit_beta isPrimaryTopicOf Interleukin_12_subunit_beta.