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- Interleukin_35 abstract "Interleukin 35 (IL-35) is an IL-12 family cytokine produced by regulatory, but not effector, T-cells and plays a role in immune suppression. It is a dimeric protein composed of IL-12α and IL-27β chains, which are encoded by two separate genes called IL12A and EBI3, respectively. Secreted by regulatory T-cells (Tregs), IL-35 suppresses inflammatory responses of immune cells. IL-35 is not constitutively expressed in tissues, but the gene encoding IL-35 is transcribed by vascular endothelial cells, smooth muscle cells and monocytes after activation with proinflammatory stimuli. Studies in mice show the absence of either IL-35 chain from regulatory Tregs reduces the cells' ability to suppress inflammation; this has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease. To produce its suppressive effects, IL-35 has selective activities on different T-cell subsets; it induces proliferation of Treg cell populations but reduces activity of Th17 cell populations.".
- Interleukin_35 wikiPageID "14358436".
- Interleukin_35 wikiPageRevisionID "591804511".
- Interleukin_35 hasPhotoCollection Interleukin_35.
- Interleukin_35 subject Category:Cytokines.
- Interleukin_35 comment "Interleukin 35 (IL-35) is an IL-12 family cytokine produced by regulatory, but not effector, T-cells and plays a role in immune suppression. It is a dimeric protein composed of IL-12α and IL-27β chains, which are encoded by two separate genes called IL12A and EBI3, respectively. Secreted by regulatory T-cells (Tregs), IL-35 suppresses inflammatory responses of immune cells.".
- Interleukin_35 label "Interleukin 35".
- Interleukin_35 sameAs m.03d1lx3.
- Interleukin_35 sameAs Q6047058.
- Interleukin_35 sameAs Q6047058.
- Interleukin_35 wasDerivedFrom Interleukin_35?oldid=591804511.
- Interleukin_35 isPrimaryTopicOf Interleukin_35.