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- Isovaline abstract "Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth suggesting a role in the origin of life.The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system. Isovaline acts as an analgesic in mice by activating peripheral GABAB receptors. In a mouse model of osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee.Isovaline does not cross the blood-brain barrier and does not enter into the brain or spinal cord. Drugs such as opioids cross the blood-brain barrier to produce analgesia but often produce confusion, sedation and addiction.Isovaline acts downstream to the cyclooxygenase system that NSAIDs inhibit, suggesting a means to avoid adverse effects such as irritation of the gastrointestinal system.This novel first-in-class compound has potential for treatment of acute and chronic pain, without the negative side effects associated with other commonly used analgesics.".
- Isovaline iupacName "2-Amino-2-methylbutanoic acid".
- Isovaline thumbnail Isovaline_Isovalin.svg?width=300.
- Isovaline wikiPageID "26008312".
- Isovaline wikiPageRevisionID "604533504".
- Isovaline hasPhotoCollection Isovaline.
- Isovaline imagefile "Isovaline_Isovalin.svg".
- Isovaline imagesize "200".
- Isovaline iupacname "2".
- Isovaline othernames "2".
- Isovaline subject Category:Amino_acids.
- Isovaline type Abstraction100002137.
- Isovaline type AminoAcid114601829.
- Isovaline type AminoAcids.
- Isovaline type Chemical114806838.
- Isovaline type Compound114818238.
- Isovaline type Material114580897.
- Isovaline type Matter100020827.
- Isovaline type OrganicCompound114727670.
- Isovaline type Part113809207.
- Isovaline type PhysicalEntity100001930.
- Isovaline type Relation100031921.
- Isovaline type Substance100019613.
- Isovaline type ChemicalCompound.
- Isovaline type ChemicalSubstance.
- Isovaline type ChemicalObject.
- Isovaline type Thing.
- Isovaline comment "Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth suggesting a role in the origin of life.The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system.".
- Isovaline label "Isovalin".
- Isovaline label "Isovalina".
- Isovaline label "Isovalina".
- Isovaline label "Isovaline".
- Isovaline label "Isovaline".
- Isovaline sameAs Isovalin.
- Isovaline sameAs Isovaline.
- Isovaline sameAs Isovalina.
- Isovaline sameAs Isovalina.
- Isovaline sameAs m.0b6f1y9.
- Isovaline sameAs Q412994.
- Isovaline sameAs Q412994.
- Isovaline sameAs Isovaline.
- Isovaline wasDerivedFrom Isovaline?oldid=604533504.
- Isovaline depiction Isovaline_Isovalin.svg.
- Isovaline isPrimaryTopicOf Isovaline.