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- J-113,397 abstract "J-113,397 is an opioid analgesic drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. It is several hundred times selective for the ORL-1 receptor over other opioid receptors, and its effects in animals include preventing the development of tolerance to morphine, the prevention of hyperalgesia induced by intracerebroventricular administration of nociceptin (orphanin FQ), as well as the stimulation of dopamine release in the striatum, which increases the rewarding effects of cocaine, but may have clinical application in the treatment of Parkinson's disease.".
- J-113,397 casNumber "217461-40-0".
- J-113,397 iupacName "1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one".
- J-113,397 pubchem "5311194".
- J-113,397 thumbnail J-113,397_structure.png?width=300.
- J-113,397 wikiPageID "20143385".
- J-113,397 wikiPageRevisionID "606554813".
- J-113,397 c "24".
- J-113,397 casNumber "217461".
- J-113,397 chembl "357076".
- J-113,397 chemspiderid "4470714".
- J-113,397 h "37".
- J-113,397 hasPhotoCollection J-113,397.
- J-113,397 inchi "1".
- J-113,397 inchikey "MBGVUMXBUGIIBQ-LEWJYISDBC".
- J-113,397 iupacName "1".
- J-113,397 iupharLigand "1691".
- J-113,397 molecularWeight "399.568".
- J-113,397 n "3".
- J-113,397 o "2".
- J-113,397 pubchem "5311194".
- J-113,397 smiles "C4CCCCCCC4CNCCC1n3c2ccccc2nc3=O".
- J-113,397 stdinchi "1".
- J-113,397 stdinchikey "MBGVUMXBUGIIBQ-LEWJYISDSA-N".
- J-113,397 synonyms "J-113,397".
- J-113,397 verifiedfields "changed".
- J-113,397 verifiedrevid "411032647".
- J-113,397 width "200".
- J-113,397 subject Category:Alcohols.
- J-113,397 subject Category:Benzimidazoles.
- J-113,397 subject Category:Piperidines.
- J-113,397 subject Category:Synthetic_opioids.
- J-113,397 subject Category:Ureas.
- J-113,397 type Drug.
- J-113,397 type DrugProduct.
- J-113,397 type FunctionalSubstance.
- J-113,397 comment "J-113,397 is an opioid analgesic drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor.".
- J-113,397 label "J-113,397".
- J-113,397 sameAs m.04y6tn3.
- J-113,397 sameAs Q12745583.
- J-113,397 sameAs Q12745583.
- J-113,397 wasDerivedFrom J-113,397?oldid=606554813.
- J-113,397 depiction J-113,397_structure.png.
- J-113,397 isPrimaryTopicOf J-113,397.