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- JQ1 abstract "JQ1 is a chemical compound which is under development as a non-hormonal male contraceptive drug. Its chemical structure is a triazolothienodiazepine, a series originally discovered by Mitsubishi Pharma [WO/2009/084693], related to benzodiazepine derivatives such as etizolam, however JQ1 does not produce sedative or anxiolytic effects and is instead a potent and selective inhibitor of the bromodomain testis-specific protein BRDT, which is essential for chromatin remodeling during spermatogenesis. By blocking BRDT, JQ1 effectively blocks the production of sperm in the testes and consequently produces effective contraception, without the negative side effects associated with previously researched hormonal contraceptives for men. JQ1 has also been investigated for other applications in the treatment of HIV infection, heart disease, and some forms of cancer.".
- JQ1 casNumber "1268524-70-4".
- JQ1 iupacName "(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate".
- JQ1 pubchem "46907787".
- JQ1 thumbnail JQ1_structure.png?width=300.
- JQ1 wikiPageID "36949002".
- JQ1 wikiPageRevisionID "606454679".
- JQ1 c "23".
- JQ1 casNumber "1268524".
- JQ1 chemspiderid "26323622".
- JQ1 cl "1".
- JQ1 h "25".
- JQ1 hasPhotoCollection JQ1.
- JQ1 inchi "1".
- JQ1 inchikey "DNVXATUJJDPFDM-KRWDZBQOBT".
- JQ1 iupacName "-tert-butyl 2-acetate".
- JQ1 molecularWeight "456.987".
- JQ1 n "4".
- JQ1 o "2".
- JQ1 pubchem "46907787".
- JQ1 s "1".
- JQ1 smiles "Cc3sc1-n2cnnc2CN=Cc4ccccc4".
- JQ1 stdinchi "1".
- JQ1 stdinchikey "DNVXATUJJDPFDM-KRWDZBQOSA-N".
- JQ1 width "200".
- JQ1 subject Category:Contraception_for_males.
- JQ1 type Drug.
- JQ1 type FunctionalSubstance.
- JQ1 comment "JQ1 is a chemical compound which is under development as a non-hormonal male contraceptive drug.".
- JQ1 label "JQ1".
- JQ1 label "JQ1".
- JQ1 label "JQ1".
- JQ1 sameAs JQ1.
- JQ1 sameAs m.0n4c2sz.
- JQ1 sameAs Q3156953.
- JQ1 sameAs Q3156953.
- JQ1 wasDerivedFrom JQ1?oldid=606454679.
- JQ1 depiction JQ1_structure.png.
- JQ1 isPrimaryTopicOf JQ1.