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- Kashin–Beck_disease abstract "Kashin–Beck disease (KBD) is a chronic, endemic osteochondropathy (disease of the bone), which is mainly distributed from northeastern to southwestern China involving 15 provinces. Tibet currently has the highest incidence rate of KBD in China. Southeast Siberia and North Korea are other affected areas. KBD usually involves children ages 5–15 and to date more than a million individuals have suffered from KBD. The symptoms of KBD include joint pain, morning stiffness in the joints, disturbances of flexion and extension in the elbows, enlarged inter-phalangeal joints and limited motion in many joints of the body. Death of cartilage cells in the growth plate and articular surface is the basic pathologic feature; this can result in growth retardation and secondary osteoarthrosis. Histological diagnosis of KBD is particularly difficult, clinical and radiological examinations have proved to be the best means for identifying KBD. Little is known about the early stages of KBD before the visible appearance of the disease becomes evident in the destruction of the joints.This disease has been recognized for over 150 years but its etiology has not yet been completely defined. Currently the accepted potential causes of KBD include mycotoxins present in grain, trace mineral deficiency in nutrition and high levels of fulvic acid in drinking water. Selenium and iodine have been considered the most important deficiencies associated with KBD. Mycotoxins produced by fungi can contaminate grain which may cause KBD because mycotoxins cause the production of free radicals. T-2 is the mycotoxin implicated with KBD, produced by members of several fungal genera. T-2 toxin can cause lesions in hematopoietic, lymphoid, gastrointestinal, and cartilage tissues, especially in physeal cartilage. Fulvic acid present in drinking water damages cartilage cells. Selenium supplementation in selenium deficient areas has been shown to prevent this disease. However, selenium supplementation in some areas showed no significant effect, proving that deficiency of selenium may not be the dominant cause in KBD.".
- Kashin–Beck_disease thumbnail Kbdpatient.jpg?width=300.
- Kashin–Beck_disease wikiPageID "14386750".
- Kashin–Beck_disease wikiPageRevisionID "591460428".
- Kashin–Beck_disease caption "Patient diagnosed with Kashin-Beck Disease".
- Kashin–Beck_disease diseasesdb "30038".
- Kashin–Beck_disease icd "716".
- Kashin–Beck_disease icd "M12.1".
- Kashin–Beck_disease name "Kashin–Beck disease".
- Kashin–Beck_disease subject Category:Health_in_China.
- Kashin–Beck_disease subject Category:Health_in_Tibet.
- Kashin–Beck_disease subject Category:Inflammatory_polyarthropathies.
- Kashin–Beck_disease subject Category:Nutritional_deficiencies.
- Kashin–Beck_disease type Disease.
- Kashin–Beck_disease type Situation.
- Kashin–Beck_disease comment "Kashin–Beck disease (KBD) is a chronic, endemic osteochondropathy (disease of the bone), which is mainly distributed from northeastern to southwestern China involving 15 provinces. Tibet currently has the highest incidence rate of KBD in China. Southeast Siberia and North Korea are other affected areas. KBD usually involves children ages 5–15 and to date more than a million individuals have suffered from KBD.".
- Kashin–Beck_disease label "Choroba Kaszina-Beka".
- Kashin–Beck_disease label "Kaschin-Beck-Krankheit".
- Kashin–Beck_disease label "Kashin–Beck disease".
- Kashin–Beck_disease label "Maladie de Kashin-Beck".
- Kashin–Beck_disease sameAs Kashin%E2%80%93Beck_disease.
- Kashin–Beck_disease sameAs Kaschin-Beck-Krankheit.
- Kashin–Beck_disease sameAs Maladie_de_Kashin-Beck.
- Kashin–Beck_disease sameAs Choroba_Kaszina-Beka.
- Kashin–Beck_disease sameAs Q500314.
- Kashin–Beck_disease sameAs Q500314.
- Kashin–Beck_disease wasDerivedFrom Kashin–Beck_disease?oldid=591460428.
- Kashin–Beck_disease depiction Kbdpatient.jpg.