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- Ketogenic_diet abstract "The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fuelling brain function. However, if there is very little carbohydrate in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures.The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories to maintain the correct weight for age and height. This classic ketogenic diet contains a 4:1 ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains and sugar, while increasing the consumption of foods high in fat such as nuts, cream and butter.Most dietary fat is made of molecules called long-chain triglycerides (LCTs). However, medium-chain triglycerides (MCTs)—made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oil, which is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.The classic therapeutic ketogenic diet was developed for treatment of paediatric epilepsy in the 1920s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant drugs. In the mid-1990s, Hollywood producer Jim Abrahams, whose son's severe epilepsy was effectively controlled by the diet, created the Charlie Foundation to promote it. Publicity included an appearance on NBC's Dateline programme and ...First Do No Harm (1997), a made-for-television film starring Meryl Streep. The foundation sponsored a multicentre research study, the results of which—announced in 1996—marked the beginning of renewed scientific interest in the diet.Almost half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet. The most common adverse effect is constipation, affecting about 30% of patients - this was due to fluid restriction, which was once a feature of the diet, but this led to increased risk of kidney stones, and is no longer considered beneficial.There is some evidence that adults with epilepsy may benefit from the diet, and that a less strict regime, such as a modified Atkins diet, is similarly effective. Clinical trials and studies in animal models suggest that ketogenic diets provide neuroprotective and disease-modifying benefits for a number of adult neurodegenerative disorders. As of 2012, there is limited clinical trial data in these areas, and, outside of paediatric epilepsy, use of the ketogenic diet remains at the research stage.".
- Ketogenic_diet thumbnail Ketonuria.jpg?width=300.
- Ketogenic_diet wikiPageExternalLink site.matthewsfriends.org.
- Ketogenic_diet wikiPageExternalLink www.charliefoundation.org.
- Ketogenic_diet wikiPageExternalLink dietary_therapies.
- Ketogenic_diet wikiPageExternalLink talk_with_john_freeman.html.
- Ketogenic_diet wikiPageExternalLink ketogenic-diet.aspx.
- Ketogenic_diet wikiPageID "791546".
- Ketogenic_diet wikiPageRevisionID "605932776".
- Ketogenic_diet align "right".
- Ketogenic_diet alt "Skeletal formula of 3-hydroxybutyric acid".
- Ketogenic_diet alt "Skeletal formula of 3-oxobutanoic acid".
- Ketogenic_diet alt "Skeletal formula of acetone".
- Ketogenic_diet caption Acetoacetic_acid.
- Ketogenic_diet caption Acetone.
- Ketogenic_diet caption Beta-Hydroxybutyric_acid.
- Ketogenic_diet colwidth "30".
- Ketogenic_diet direction "vertical".
- Ketogenic_diet group "Note".
- Ketogenic_diet hasPhotoCollection Ketogenic_diet.
- Ketogenic_diet header Ketone_bodies.
- Ketogenic_diet image "Acetoacetic acid-2D-skeletal.svg".
- Ketogenic_diet image "Acetone-2D-skeletal.svg".
- Ketogenic_diet image "beta-Hydroxybutyric acid-2D-skeletal.svg".
- Ketogenic_diet refs "ref|Ketogenic "eggnog" is used during induction and is a drink with the required ketogenic ratio. For example, a 4:1 ratio eggnog would contain 60 g of 36% heavy whipping cream, 25 g pasteurised raw egg, vanilla and saccharin flavour. This contains 245 kcal (1,025 kJ), 4 g protein, 2 g carbohydrate and 24 g fat (24:6 = 4:1). The eggnog may also be cooked to make a custard, or frozen to make ice cream.|group="Note"|name="Eggnog"".
- Ketogenic_diet width "150".
- Ketogenic_diet width "75".
- Ketogenic_diet subject Category:Diets.
- Ketogenic_diet subject Category:Epilepsy.
- Ketogenic_diet subject Category:High-fat_diets.
- Ketogenic_diet subject Category:Low-carb_diets.
- Ketogenic_diet type Diet107561112.
- Ketogenic_diet type Diets.
- Ketogenic_diet type Fare107560652.
- Ketogenic_diet type Food100021265.
- Ketogenic_diet type High-fatDiets.
- Ketogenic_diet type Low-carbDiets.
- Ketogenic_diet type Matter100020827.
- Ketogenic_diet type PhysicalEntity100001930.
- Ketogenic_diet type Substance100020090.
- Ketogenic_diet comment "The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fuelling brain function.".
- Ketogenic_diet label "Dieta cetogénica".
- Ketogenic_diet label "Diète cétogène".
- Ketogenic_diet label "Ketogeen dieet".
- Ketogenic_diet label "Ketogene Diät".
- Ketogenic_diet label "Ketogenic diet".
- Ketogenic_diet label "Кето-диета".
- Ketogenic_diet label "生酮飲食".
- Ketogenic_diet sameAs Ketogene_Diät.
- Ketogenic_diet sameAs Dieta_cetogénica.
- Ketogenic_diet sameAs Diète_cétogène.
- Ketogenic_diet sameAs Diet_ketogenik.
- Ketogenic_diet sameAs Ketogeen_dieet.
- Ketogenic_diet sameAs m.03cg86.
- Ketogenic_diet sameAs Q1070684.
- Ketogenic_diet sameAs Q1070684.
- Ketogenic_diet sameAs Ketogenic_diet.
- Ketogenic_diet wasDerivedFrom Ketogenic_diet?oldid=605932776.
- Ketogenic_diet depiction Ketonuria.jpg.
- Ketogenic_diet isPrimaryTopicOf Ketogenic_diet.