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- Koala_retrovirus abstract "Koala retrovirus (KoRV) is a retrovirus that is present in many populations of koalas. It has been implicated as the agent of Koala Immune Deficiency Syndrome (KIDS), an AIDS-like immunodeficiency that leaves infected koalas more susceptible to infectious disease and cancers. The virus is thought to be a recently introduced exogenous virus that is also integrating into the koala genome (becoming endogenous). Thus the virus can transmit both horizontally (from animal to animal in the classic sense) and vertically (from parent to offspring as a gene). The horizontal modes of transmission are not well defined but are thought to require close contact.Koala retrovirus was initially described as a novel endogenous retrovirus found within the koala genome and in tissues as free virions. Viral DNA sequence analysis showed intact open reading frames and pathogenic DNA motifs strongly suggesting that KoRV is an active replicating endogenous virus that can also produce infectious virions. The analysis also showed that KoRV was closely related to the highly pathogenic Gibbon Ape Leukemia Virus (GALV). The epidemiology of how koalas and gibbons came to share such similar viruses remains unclear.The virus has been attributed to 80% of deaths in captive koalas in Queensland from leukaemia, lymphoma, malignant tumours and immune deficiency disorders. In 2008, lead researcher Jon Hanger, said the virus was a threat that could lead to extinction of koalas in Queensland within 15 years, claiming 100% infection rates in studied populations that suggest an epidemic.Research has also shown that some populations of koalas, particularly an isolated colony on Kangaroo Island do not appear to have the endogenous form of the retrovirus. This suggests that the virus gene sequence is a new acquisition for the koala genome. Prevalence of KoRV (and KIDS) in Australian koala populations suggests a trend spreading from the north down to the south of Australia. Northern populations are completely infected, while some southern populations (including Kangaroo Island) are free. Prior to this 'koala retrovirus' was used to refer to an unidentified oncovirus detected in cancer-affected koalas.It is thought that further studying KoRV will allow valuable insight into how endogenous retrovirus develop and incorporate themselves into mammalian genomes.".
- Koala_retrovirus colourName "violet".
- Koala_retrovirus family Retrovirus.
- Koala_retrovirus genus Gammaretrovirus.
- Koala_retrovirus wikiPageID "18308287".
- Koala_retrovirus wikiPageRevisionID "599263217".
- Koala_retrovirus color "violet".
- Koala_retrovirus familia "Retroviridae".
- Koala_retrovirus genus "Gammaretrovirus".
- Koala_retrovirus hasPhotoCollection Koala_retrovirus.
- Koala_retrovirus name "Koala retrovirus".
- Koala_retrovirus subdivision "unclassified Gammaretrovirus".
- Koala_retrovirus subdivisionRanks "species".
- Koala_retrovirus virusGroup "vi".
- Koala_retrovirus subject Category:Gammaretroviruses.
- Koala_retrovirus subject Category:Koalas.
- Koala_retrovirus type Animal100015388.
- Koala_retrovirus type Chordate101466257.
- Koala_retrovirus type Koala101882714.
- Koala_retrovirus type Koalas.
- Koala_retrovirus type LivingThing100004258.
- Koala_retrovirus type Mammal101861778.
- Koala_retrovirus type Marsupial101874434.
- Koala_retrovirus type Metatherian101873982.
- Koala_retrovirus type Object100002684.
- Koala_retrovirus type Organism100004475.
- Koala_retrovirus type Phalanger101881171.
- Koala_retrovirus type PhysicalEntity100001930.
- Koala_retrovirus type Vertebrate101471682.
- Koala_retrovirus type Whole100003553.
- Koala_retrovirus type Species.
- Koala_retrovirus type Organism.
- Koala_retrovirus comment "Koala retrovirus (KoRV) is a retrovirus that is present in many populations of koalas. It has been implicated as the agent of Koala Immune Deficiency Syndrome (KIDS), an AIDS-like immunodeficiency that leaves infected koalas more susceptible to infectious disease and cancers. The virus is thought to be a recently introduced exogenous virus that is also integrating into the koala genome (becoming endogenous).".
- Koala_retrovirus label "Koala retrovirus".
- Koala_retrovirus label "Koala-Retrovirus".
- Koala_retrovirus sameAs Koala-Retrovirus.
- Koala_retrovirus sameAs m.04cwx3y.
- Koala_retrovirus sameAs Q4678387.
- Koala_retrovirus sameAs Q4678387.
- Koala_retrovirus sameAs Koala_retrovirus.
- Koala_retrovirus wasDerivedFrom Koala_retrovirus?oldid=599263217.
- Koala_retrovirus isPrimaryTopicOf Koala_retrovirus.
- Koala_retrovirus name "Koala retrovirus".