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- Ku80 abstract "Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is required for telomere length maintenance and subtelomeric gene silencing.Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.Ku80 has been referred to by several names including: Lupus Ku autoantigen protein p80 ATP-dependent DNA helicase 2 subunit 2 X-ray repair complementing defective repair in Chinese hamster cells 5 X-ray repair cross-complementing 5 (XRCC5)↑ 1.0 1.1 ↑".
- Ku80 entrezgene "7520".
- Ku80 wikiPageID "14073903".
- Ku80 wikiPageRevisionID "592139088".
- Ku80 hasPhotoCollection Ku80.
- Ku80 requireManualInspection "no".
- Ku80 updateCitations "yes".
- Ku80 updatePage "yes".
- Ku80 updateProteinBox "yes".
- Ku80 updateSummary "yes".
- Ku80 type Biomolecule.
- Ku80 type Protein.
- Ku80 type BiologicalObject.
- Ku80 comment "Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair.".
- Ku80 label "Ku80".
- Ku80 label "Ku80".
- Ku80 label "Ku80".
- Ku80 label "Ku80".
- Ku80 sameAs Ku80.
- Ku80 sameAs Ku80.
- Ku80 sameAs m.03csr33.
- Ku80 sameAs Q2088530.
- Ku80 sameAs Q2088530.
- Ku80 wasDerivedFrom Ku80?oldid=592139088.
- Ku80 isPrimaryTopicOf Ku80.