Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Ku_(protein)> ?p ?o. }
- Ku_(protein) abstract "Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to human. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. The two Ku subunits form a basket-shaped structure that threads onto the DNA end. Once bound, Ku can slide down the DNA strand, allowing more Ku molecules to thread onto the end. In higher eukaryotes, Ku forms a complex with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the full DNA-dependent protein kinase, DNA-PK. Ku is thought to function as a molecular scaffold to which other proteins involved in NHEJ can bind.Both subunits of Ku have been experimentally knocked out in mice. These mice exhibit chromosomal instability, indicating that NHEJ is important for genome maintenance.In many organisms, Ku has additional functions at telomeres in addition to its role in DNA repair.Abundance of Ku80 seems to be related to species longevity.The Ku70 and Ku80 proteins consist of three structural domains. The N-terminal domain is an alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold. The central domain of Ku70 and Ku80 is a DNA-binding beta-barrel domain. Ku makes only a few contacts with the sugar-phosphate backbone, and none with the DNA bases, but it fits sterically to major and minor groove contours forming a ring that encircles duplex DNA, cradling two full turns of the DNA molecule. By forming a bridge between the broken DNA ends, Ku acts to structurally support and align the DNA ends, to protect them from degradation, and to prevent promiscuous binding to unbroken DNA. Ku effectively aligns the DNA, while still allowing access of polymerases, nucleases and ligases to the broken DNA ends to promote end joining. The C-terminal arm is an alpha helical region which embraces the central beta-barrel domain of the opposite subunit. In some cases a fourth domain is present at the C-terminus, which binds to DNA-dependent protein kinase catalytic subunit.".
- Ku_(protein) arm "q".
- Ku_(protein) band "11".
- Ku_(protein) band "35".
- Ku_(protein) chromosome "2".
- Ku_(protein) chromosome "22".
- Ku_(protein) entrezgene "2547".
- Ku_(protein) entrezgene "7520".
- Ku_(protein) hgncid "12833".
- Ku_(protein) hgncid "4055".
- Ku_(protein) locusSupplementaryData "-q13".
- Ku_(protein) omim "152690".
- Ku_(protein) omim "194364".
- Ku_(protein) pdb "1JEY".
- Ku_(protein) refseq "NM_001469".
- Ku_(protein) refseq "NM_021141".
- Ku_(protein) symbol "Ku".
- Ku_(protein) symbol "Ku70, G22P1".
- Ku_(protein) symbol "Ku80".
- Ku_(protein) symbol "Ku_C".
- Ku_(protein) symbol "Ku_N".
- Ku_(protein) symbol "Ku_PK_bind".
- Ku_(protein) symbol "XRCC5".
- Ku_(protein) symbol "XRCC6".
- Ku_(protein) thumbnail Ku_bound_to_DNA.png?width=300.
- Ku_(protein) uniprot "P12956".
- Ku_(protein) uniprot "P13010".
- Ku_(protein) wikiPageID "5058843".
- Ku_(protein) wikiPageRevisionID "592139029".
- Ku_(protein) altsymbols "Ku70, G22P1".
- Ku_(protein) altsymbols "Ku80".
- Ku_(protein) arm "q".
- Ku_(protein) band "11".
- Ku_(protein) band "35".
- Ku_(protein) caption "259200.0".
- Ku_(protein) caption "Crystal structure of human Ku bound to DNA. Ku70 is shown in purple, Ku80 in blue, and the DNA strand in green.".
- Ku_(protein) caption "crystal structure of the ku heterodimer bound to dna".
- Ku_(protein) caption "crystal structure of the ku heterodimer".
- Ku_(protein) chromosome "2".
- Ku_(protein) chromosome "22".
- Ku_(protein) entrezgene "2547".
- Ku_(protein) entrezgene "7520".
- Ku_(protein) hasPhotoCollection Ku_(protein).
- Ku_(protein) hgncid "12833".
- Ku_(protein) hgncid "4055".
- Ku_(protein) interpro "IPR005160".
- Ku_(protein) interpro "IPR005161".
- Ku_(protein) interpro "IPR006164".
- Ku_(protein) interpro "IPR014893".
- Ku_(protein) locussupplementarydata "-q13".
- Ku_(protein) name "Ku C terminal domain like".
- Ku_(protein) name "Ku70/Ku80 C-terminal arm".
- Ku_(protein) name "Ku70/Ku80 N-terminal alpha/beta domain".
- Ku_(protein) name "Ku70/Ku80 beta-barrel domain".
- Ku_(protein) name "X-ray repair".
- Ku_(protein) name "cross-complementing 5".
- Ku_(protein) name "cross-complementing 6".
- Ku_(protein) omim "152690".
- Ku_(protein) omim "194364".
- Ku_(protein) pdb "1".
- Ku_(protein) pfam "PF02735".
- Ku_(protein) pfam "PF03730".
- Ku_(protein) pfam "PF03731".
- Ku_(protein) pfam "PF08785".
- Ku_(protein) pfamClan "CL0128".
- Ku_(protein) prosite "PDOC00252".
- Ku_(protein) refseq "NM_001469".
- Ku_(protein) refseq "NM_021141".
- Ku_(protein) scop "1".
- Ku_(protein) symbol Ku70.
- Ku_(protein) symbol Ku80.
- Ku_(protein) symbol "Ku".
- Ku_(protein) symbol "Ku_C".
- Ku_(protein) symbol "Ku_N".
- Ku_(protein) symbol "Ku_PK_bind".
- Ku_(protein) uniprot "P12956".
- Ku_(protein) uniprot "P13010".
- Ku_(protein) subject Category:DNA_repair.
- Ku_(protein) subject Category:Protein_domains.
- Ku_(protein) subject Category:Protein_families.
- Ku_(protein) subject Category:Proteins.
- Ku_(protein) type Abstraction100002137.
- Ku_(protein) type Attribute100024264.
- Ku_(protein) type Chemical114806838.
- Ku_(protein) type Compound114818238.
- Ku_(protein) type Environment113934596.
- Ku_(protein) type Macromolecule114944888.
- Ku_(protein) type Material114580897.
- Ku_(protein) type Matter100020827.
- Ku_(protein) type Molecule114682133.
- Ku_(protein) type OrganicCompound114727670.
- Ku_(protein) type Part113809207.
- Ku_(protein) type PhysicalEntity100001930.
- Ku_(protein) type Protein114728724.
- Ku_(protein) type ProteinDomains.
- Ku_(protein) type Proteins.
- Ku_(protein) type Relation100031921.
- Ku_(protein) type Situation113927383.
- Ku_(protein) type Sphere114514039.
- Ku_(protein) type State100024720.