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- L-733,060 abstract "L-733,060 is a drug developed by Merck, Sharpe & Dohme which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury. It also has anticancer effects in a variety of in vitro models.".
- L-733,060 casNumber "148700-85-0".
- L-733,060 iupacName "(2S,3S)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenylpiperidine".
- L-733,060 pubchem "132846".
- L-733,060 thumbnail L-733,060_structure.png?width=300.
- L-733,060 wikiPageID "20233517".
- L-733,060 wikiPageRevisionID "593616559".
- L-733,060 c "20".
- L-733,060 casNumber "148700".
- L-733,060 chembl "27006".
- L-733,060 f "6".
- L-733,060 h "19".
- L-733,060 hasPhotoCollection L-733,060.
- L-733,060 iupacName "-3".
- L-733,060 molecularWeight "403.361".
- L-733,060 n "1".
- L-733,060 o "1".
- L-733,060 pubchem "132846".
- L-733,060 smiles "FCccccc2COC1CCCNC1c3ccccc3".
- L-733,060 verifiedfields "changed".
- L-733,060 verifiedrevid "438696640".
- L-733,060 watchedfields "changed".
- L-733,060 width "220".
- L-733,060 subject Category:Antidepressants.
- L-733,060 subject Category:Anxiolytics.
- L-733,060 subject Category:Ethers.
- L-733,060 subject Category:NK1_receptor_antagonists.
- L-733,060 subject Category:Organofluorides.
- L-733,060 subject Category:Piperidines.
- L-733,060 type Drug.
- L-733,060 type DrugProduct.
- L-733,060 type FunctionalSubstance.
- L-733,060 comment "L-733,060 is a drug developed by Merck, Sharpe & Dohme which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine.".
- L-733,060 label "L-733,060".
- L-733,060 sameAs m.04zyd7t.
- L-733,060 sameAs Q6456079.
- L-733,060 sameAs Q6456079.
- L-733,060 wasDerivedFrom L-733,060?oldid=593616559.
- L-733,060 depiction L-733,060_structure.png.
- L-733,060 isPrimaryTopicOf L-733,060.
