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- LHX1 abstract "LIM homeobox 1, also known as LHX1, is a gene.This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.The Lim gene family is a subfamily of homeobox genes. The homeobox genes are essential in organizing the body plan of an organism and all contain the same conserved homeodomain of amino acids. Evidence that Lim-1 is essential to a developing organism is its conservation throughout evolution and presence in a variety of organisms. The Lim-1 gene encodes a transcription factor which binds to the DNA of specific genes and functions to produce the needed gene product for development of the organism. Lim-1 is important during early molecular development and is required in both primitive streak-derived tissue and visceral endoderm of the early embryo for development of a head. Studies done using mutant organisms without the Lim gene results in organisms that develop no head structure at all support the essential role of the Lim-1 gene in formation of the head. This gene has also been shown to play a crucial role in the formation of the female reproductive tract. The gene is expressed in the developing Müllerian duct of females, and when the gene is knocked out no reproductive tract forms.".
- LHX1 entrezgene "3975".
- LHX1 wikiPageID "15346583".
- LHX1 wikiPageRevisionID "592185879".
- LHX1 hasPhotoCollection LHX1.
- LHX1 requireManualInspection "no".
- LHX1 summaryText "This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.".
- LHX1 updateCitations "yes".
- LHX1 updatePage "yes".
- LHX1 updateProteinBox "yes".
- LHX1 updateSummary "yes".
- LHX1 type Biomolecule.
- LHX1 type Protein.
- LHX1 type BiologicalObject.
- LHX1 comment "LIM homeobox 1, also known as LHX1, is a gene.This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.The Lim gene family is a subfamily of homeobox genes.".
- LHX1 label "LHX1".
- LHX1 label "LHX1".
- LHX1 sameAs LHX1.
- LHX1 sameAs m.03m5rv0.
- LHX1 sameAs Q6458565.
- LHX1 sameAs Q6458565.
- LHX1 wasDerivedFrom LHX1?oldid=592185879.
- LHX1 isPrimaryTopicOf LHX1.