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- LIM_domain abstract "LIM domains are protein structural domains, composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. They are named after their initial discovery in the proteins Lin11, Isl-1 & Mec-3. LIM-domain containing proteins have been shown to play roles in cytoskeletal organisation, organ development and oncogenesis. LIM-domains mediate protein:protein interactions that are critical to cellular processes. LIM domains have highly divergent sequences, apart from certain key residues. The sequence divergence allow a great many different binding sites to be grafted onto the same basic domain. The conserved residues are those involved in zinc binding or the hydrophobic core of the protein. The sequence signature of LIM domains is as follows:[C]-[X]2-4-[C]-[X]13-19-[W]-[H]-[X]2-4-[C]-[F]-[LVI]-[C]-[X]2-4-[C]-[X]13-20-C-[X]2-4-[C]LIM domains frequently occur in multiples, as seen in proteins such as TES, LMO4, and can also be attached to other domains in order to confer a binding or targeting function upon them, such as LIM-kinase.The LIM superclass of genes have been classified into 14 classes: ABLIM, CRP, ENIGMA, EPLIN, LASP, LHX, LMO, LIMK, LMO7, MICAL, PXN, PINCH, TES, and ZYX. Six of these classes (i.e., ABLIM, MICAL, ENIGMA, ZYX, LHX, LM07) originated in the stem lineage of animals, and this expansion is thought to have made a major contribution to the origin of animal multicellularity. LIM domains are also found in various bacterial lineages where they are typically fused to a metallopeptidase domain. Some versions show fusions to an inactive P-loop NTPase at their N-terminus and a single transmembrane helix. These domain fusions suggest that the prokaryotic LIM domains are likely to regulate protein processing at the cell membrane. The domain architectural syntax is remarkable parallel to those of the prokaryotic versions of the B-box zinc finger and the AN1 zinc finger domains.".
- LIM_domain symbol "LIM".
- LIM_domain thumbnail Lims.png?width=300.
- LIM_domain wikiPageID "9053177".
- LIM_domain wikiPageRevisionID "592192356".
- LIM_domain caption "Structure of the 4th LIM domain of Pinch protein. Zinc atoms are shown in grey".
- LIM_domain cdd "cd08368".
- LIM_domain hasPhotoCollection LIM_domain.
- LIM_domain interpro "IPR001781".
- LIM_domain name "LIM domain".
- LIM_domain pdb "A:11-67".
- LIM_domain pfam "PF00412".
- LIM_domain prosite "PDOC50178".
- LIM_domain scop "1".
- LIM_domain symbol "LIM".
- LIM_domain width "200".
- LIM_domain subject Category:Protein_domains.
- LIM_domain subject Category:Transcription_factors.
- LIM_domain type Abstraction100002137.
- LIM_domain type Attribute100024264.
- LIM_domain type Beginning107290905.
- LIM_domain type Cause107326557.
- LIM_domain type Environment113934596.
- LIM_domain type Event100029378.
- LIM_domain type Factor107327805.
- LIM_domain type Happening107283608.
- LIM_domain type Origin107323922.
- LIM_domain type ProteinDomains.
- LIM_domain type PsychologicalFeature100023100.
- LIM_domain type Situation113927383.
- LIM_domain type Sphere114514039.
- LIM_domain type State100024720.
- LIM_domain type TranscriptionFactors.
- LIM_domain type YagoPermanentlyLocatedEntity.
- LIM_domain type Biomolecule.
- LIM_domain type Protein.
- LIM_domain type BiologicalObject.
- LIM_domain comment "LIM domains are protein structural domains, composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. They are named after their initial discovery in the proteins Lin11, Isl-1 & Mec-3. LIM-domain containing proteins have been shown to play roles in cytoskeletal organisation, organ development and oncogenesis. LIM-domains mediate protein:protein interactions that are critical to cellular processes.".
- LIM_domain label "Dominio LIM".
- LIM_domain label "LIM domain".
- LIM_domain sameAs Dominio_LIM.
- LIM_domain sameAs m.027vylb.
- LIM_domain sameAs Q4864545.
- LIM_domain sameAs Q4864545.
- LIM_domain sameAs LIM_domain.
- LIM_domain wasDerivedFrom LIM_domain?oldid=592192356.
- LIM_domain depiction Lims.png.
- LIM_domain isPrimaryTopicOf LIM_domain.