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- La_domain abstract "In molecular biology, the La domain is a conserved protein domain.Human 60 kDa SS-A/Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and an RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif.Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses.".
- La_domain symbol "La".
- La_domain thumbnail PDB_2cqk_EBI.jpg?width=300.
- La_domain wikiPageID "34544873".
- La_domain wikiPageRevisionID "592143408".
- La_domain caption "solution structure of the la domain of c-mpl binding protein".
- La_domain cdd "cd07323".
- La_domain hasPhotoCollection La_domain.
- La_domain interpro "IPR006630".
- La_domain merops "I75".
- La_domain name "La domain".
- La_domain pfam "PF05383".
- La_domain prosite "PDOC00280".
- La_domain scop "2".
- La_domain smart "TSPN".
- La_domain symbol "La".
- La_domain tcdb "1".
- La_domain subject Category:Protein_domains.
- La_domain type Abstraction100002137.
- La_domain type Attribute100024264.
- La_domain type Environment113934596.
- La_domain type ProteinDomains.
- La_domain type Situation113927383.
- La_domain type Sphere114514039.
- La_domain type State100024720.
- La_domain type Biomolecule.
- La_domain type Protein.
- La_domain type BiologicalObject.
- La_domain comment "In molecular biology, the La domain is a conserved protein domain.Human 60 kDa SS-A/Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor.".
- La_domain label "La domain".
- La_domain sameAs m.0j29626.
- La_domain sameAs Q6466106.
- La_domain sameAs Q6466106.
- La_domain sameAs La_domain.
- La_domain wasDerivedFrom La_domain?oldid=592143408.
- La_domain depiction PDB_2cqk_EBI.jpg.
- La_domain isPrimaryTopicOf La_domain.