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- Lactacystin abstract "Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first described in 1991. The first total synthesis of lactacystin was developed by Elias Corey in 1992. Lactacystin binds and inhibits specific catalytic subunits of the proteasome, a protein complex responsible for the bulk of proteolysis in the cell, as well as proteolytic activation of certain protein substrates. It was the first non-peptidic proteasome inhibitor discovered and is widely used as a research tool in biochemistry and cell biology. It covalently modifies the amino-terminal threonine of specific catalytic subunits of the proteasome, a discovery helped to establish the proteasome as a mechanistically novel class of protease: an amino-terminal threonine protease. The molecule is most commonly used as in biochemistry and cell biology laboratories as a selective inhibitor of the proteasome. The molecule is a lactam, or cyclic amide. A number of syntheses of this molecule have been published and there are more than 1,500 citationsfor lactacystin in PubMed as of 2013.".
- Lactacystin iupacName "2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid".
- Lactacystin thumbnail Lactacystin.svg?width=300.
- Lactacystin wikiPageID "8226997".
- Lactacystin wikiPageRevisionID "586659298".
- Lactacystin hasPhotoCollection Lactacystin.
- Lactacystin imagefile "Lactacystin.svg".
- Lactacystin imagename "Stereo skeletal formula of lactacystin".
- Lactacystin imagesize "244".
- Lactacystin iupacname "2".
- Lactacystin verifiedfields "changed".
- Lactacystin verifiedrevid "400128403".
- Lactacystin watchedfields "changed".
- Lactacystin subject Category:Acetamides.
- Lactacystin subject Category:Alcohols.
- Lactacystin subject Category:Pyrrolidones.
- Lactacystin type Abstraction100002137.
- Lactacystin type Acetamide114711197.
- Lactacystin type Acetamides.
- Lactacystin type Agent114778436.
- Lactacystin type Alcohol107884567.
- Lactacystin type Alcohols.
- Lactacystin type Amide114724264.
- Lactacystin type Beverage107881800.
- Lactacystin type CausalAgent100007347.
- Lactacystin type Chemical114806838.
- Lactacystin type Compound114818238.
- Lactacystin type Drug103247620.
- Lactacystin type DrugOfAbuse103248958.
- Lactacystin type Fluid114939900.
- Lactacystin type Food100021265.
- Lactacystin type Liquid114940386.
- Lactacystin type Material114580897.
- Lactacystin type Matter100020827.
- Lactacystin type OrganicCompound114727670.
- Lactacystin type Part113809207.
- Lactacystin type PhysicalEntity100001930.
- Lactacystin type Relation100031921.
- Lactacystin type Substance100019613.
- Lactacystin type Substance100020090.
- Lactacystin type ChemicalCompound.
- Lactacystin type ChemicalSubstance.
- Lactacystin type ChemicalSubstanceType.
- Lactacystin type ChemicalObject.
- Lactacystin type Thing.
- Lactacystin comment "Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first described in 1991. The first total synthesis of lactacystin was developed by Elias Corey in 1992. Lactacystin binds and inhibits specific catalytic subunits of the proteasome, a protein complex responsible for the bulk of proteolysis in the cell, as well as proteolytic activation of certain protein substrates.".
- Lactacystin label "Lactacystin".
- Lactacystin label "Lactacystin".
- Lactacystin label "ラクタシスチン".
- Lactacystin sameAs Lactacystin.
- Lactacystin sameAs ラクタシスチン.
- Lactacystin sameAs m.026wwwc.
- Lactacystin sameAs Q6468907.
- Lactacystin sameAs Q6468907.
- Lactacystin sameAs Lactacystin.
- Lactacystin wasDerivedFrom Lactacystin?oldid=586659298.
- Lactacystin depiction Lactacystin.svg.
- Lactacystin isPrimaryTopicOf Lactacystin.