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- Lapaquistat abstract "Lapaquistat (TAK-475) is a cholesterol-lowering drug. Unlike statins, which inhibit HMG-CoA reductase, lapaquistat metabolites inhibit squalene synthase, which is further downstream in the synthesis of cholesterol. It is hoped that side effects can be reduced by not disturbing the mevalonate pathway, which is important for other biochemical molecules besides cholesterol.However, there is increasing evidence that statins (which inhibit the mevalonate pathway) may be clinically useful because they affect these other molecules (including protein prenylation).On March 28, 2008, Takeda halted further development of lapaquistat.".
- Lapaquistat atcPrefix "none".
- Lapaquistat casNumber "189059-71-0".
- Lapaquistat fdaUniiCode "PEZ79BV72X".
- Lapaquistat iupacName "(1-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}piperidin-4-yl)acetic acid".
- Lapaquistat pubchem "9960389".
- Lapaquistat thumbnail Lapaquistat.svg?width=300.
- Lapaquistat wikiPageID "14387852".
- Lapaquistat wikiPageRevisionID "592154323".
- Lapaquistat atcPrefix "none".
- Lapaquistat c "31".
- Lapaquistat casNumber "189059".
- Lapaquistat chembl "341976".
- Lapaquistat chemspiderid "8135996".
- Lapaquistat cl "1".
- Lapaquistat h "39".
- Lapaquistat hasPhotoCollection Lapaquistat.
- Lapaquistat inchi "1".
- Lapaquistat inchikey "HDGUKVZPMPJBFK-LEAFIULHBZ".
- Lapaquistat iupacName "acetic acid".
- Lapaquistat molecularWeight "603.103".
- Lapaquistat n "2".
- Lapaquistat o "8".
- Lapaquistat pubchem "9960389".
- Lapaquistat smiles "O=CCC4CCNCC4".
- Lapaquistat stdinchi "1".
- Lapaquistat stdinchikey "HDGUKVZPMPJBFK-LEAFIULHSA-N".
- Lapaquistat unii "PEZ79BV72X".
- Lapaquistat verifiedfields "changed".
- Lapaquistat verifiedrevid "462088993".
- Lapaquistat subject Category:Amides.
- Lapaquistat subject Category:Benzoxazepines.
- Lapaquistat subject Category:Hypolipidemic_agents.
- Lapaquistat subject Category:Organochlorides.
- Lapaquistat subject Category:Phenol_ethers.
- Lapaquistat subject Category:Piperidines.
- Lapaquistat type Abstraction100002137.
- Lapaquistat type Amide114724264.
- Lapaquistat type Amides.
- Lapaquistat type Chemical114806838.
- Lapaquistat type Compound114818238.
- Lapaquistat type Element114840755.
- Lapaquistat type Material114580897.
- Lapaquistat type Matter100020827.
- Lapaquistat type OrganicCompound114727670.
- Lapaquistat type Part113809207.
- Lapaquistat type PhenolEthers.
- Lapaquistat type PhysicalEntity100001930.
- Lapaquistat type Quintessence114847103.
- Lapaquistat type Relation100031921.
- Lapaquistat type Substance100019613.
- Lapaquistat type Drug.
- Lapaquistat type DrugProduct.
- Lapaquistat type FunctionalSubstance.
- Lapaquistat comment "Lapaquistat (TAK-475) is a cholesterol-lowering drug. Unlike statins, which inhibit HMG-CoA reductase, lapaquistat metabolites inhibit squalene synthase, which is further downstream in the synthesis of cholesterol.".
- Lapaquistat label "Lapaquistat".
- Lapaquistat sameAs m.03d2785.
- Lapaquistat sameAs Q6488102.
- Lapaquistat sameAs Q6488102.
- Lapaquistat sameAs Lapaquistat.
- Lapaquistat wasDerivedFrom Lapaquistat?oldid=592154323.
- Lapaquistat depiction Lapaquistat.svg.
- Lapaquistat isPrimaryTopicOf Lapaquistat.