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- Ledipasvir abstract "Ledipasvir (formerly GS-5885) is an experimental drug for the treatment of hepatitis C being developed by Gilead Sciences. After completing Phase III clinical trials, on Feb 10, 2014 Gilead filed for U.S. Approval of a Ledipasvir/Sofosbuvir Fixed-Dose combination tablet for Genotype 1 Hepatitis C. The Solvadi (sufosbuvir) /Ledipasvir combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without peg-interferon.Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein.Data presented at the 20th Conference on Retroviruses and Opportunistic Infections in March 2013 showed that a triple regimen of the nucleotide analogue inhibitor sofosbuvir, ledipasvir, and ribavirin produced a 12-week post-treatment sustained virological response (SVR12) rate of 100% for both treatment-naive patients and prior non-responders with HCV genotype 1. Gilead is developing a sofosbuvir + ledipasvir coformulation that is being tested with and without ribavirin. In February 2014 Gilead has filed for FDA approval of ledipasvir + sofosbuvir oral treatment, without interferon and ribavirin.".
- Ledipasvir atcPrefix "none".
- Ledipasvir casNumber "1256388-51-8".
- Ledipasvir iupacName "Methyl N-[(2S)-1-[(6S)-6-[5-[9,9-Difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate".
- Ledipasvir thumbnail Ledipasvir.svg?width=300.
- Ledipasvir wikiPageID "38749538".
- Ledipasvir wikiPageRevisionID "602515022".
- Ledipasvir atcPrefix "none".
- Ledipasvir c "49".
- Ledipasvir casNumber "1256388".
- Ledipasvir chemspiderid "29271894".
- Ledipasvir drugName "Ledipasvir".
- Ledipasvir f "2".
- Ledipasvir h "54".
- Ledipasvir inchi "1".
- Ledipasvir inchikey "VRTWBAAJJOHBQU-KMWAZVGDBR".
- Ledipasvir iupacName "Methyl N-[-1-[-6-[5-[9,9-Difluoro-7-[2-[-3-[-2--3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbamate".
- Ledipasvir legalStatus "Investigational".
- Ledipasvir molecularWeight "889".
- Ledipasvir n "8".
- Ledipasvir o "6".
- Ledipasvir smiles "CC[C@@H]NCOC".
- Ledipasvir stdinchi "1".
- Ledipasvir stdinchikey "VRTWBAAJJOHBQU-KMWAZVGDSA-N".
- Ledipasvir subject Category:Anti-RNA_virus_drugs.
- Ledipasvir subject Category:Benzimidazoles.
- Ledipasvir subject Category:Carbamates.
- Ledipasvir subject Category:Cyclopropanes.
- Ledipasvir subject Category:Fluorenes.
- Ledipasvir subject Category:Hepatitis_C.
- Ledipasvir subject Category:Imidazoles.
- Ledipasvir type Drug.
- Ledipasvir type FunctionalSubstance.
- Ledipasvir comment "Ledipasvir (formerly GS-5885) is an experimental drug for the treatment of hepatitis C being developed by Gilead Sciences. After completing Phase III clinical trials, on Feb 10, 2014 Gilead filed for U.S. Approval of a Ledipasvir/Sofosbuvir Fixed-Dose combination tablet for Genotype 1 Hepatitis C.".
- Ledipasvir label "Ledipasvir".
- Ledipasvir sameAs Ledipasvir.
- Ledipasvir sameAs m.0rffj1_.
- Ledipasvir sameAs Q15409409.
- Ledipasvir sameAs Q15409409.
- Ledipasvir wasDerivedFrom Ledipasvir?oldid=602515022.
- Ledipasvir depiction Ledipasvir.svg.
- Ledipasvir isPrimaryTopicOf Ledipasvir.
- Ledipasvir name "Ledipasvir".