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- Leonard_R._Stephens abstract "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo.They - in parallel with Dario Alessi - identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival.".
- Leonard_R._Stephens alias "Stephens, Len".
- Leonard_R._Stephens birthDate "1960-06-18".
- Leonard_R._Stephens birthYear "1960".
- Leonard_R._Stephens field Immunology.
- Leonard_R._Stephens field Signal_transduction.
- Leonard_R._Stephens nationality United_Kingdom.
- Leonard_R._Stephens residence United_Kingdom.
- Leonard_R._Stephens wikiPageExternalLink stephens.
- Leonard_R._Stephens wikiPageID "41644229".
- Leonard_R._Stephens wikiPageRevisionID "602191219".
- Leonard_R._Stephens alternativeNames "Stephens, Len".
- Leonard_R._Stephens dateOfBirth "1960-06-18".
- Leonard_R._Stephens field Immunology.
- Leonard_R._Stephens field Signal_transduction.
- Leonard_R._Stephens name "Len Stephens".
- Leonard_R._Stephens name "Stephens, Leonard R".
- Leonard_R._Stephens nationality United_Kingdom.
- Leonard_R._Stephens residence United_Kingdom.
- Leonard_R._Stephens shortDescription "British scientist".
- Leonard_R._Stephens workInstitutions Babraham_Institute.
- Leonard_R._Stephens description "British scientist".
- Leonard_R._Stephens description "British scientist".
- Leonard_R._Stephens subject Category:1960_births.
- Leonard_R._Stephens subject Category:Academics_of_the_University_of_Cambridge.
- Leonard_R._Stephens subject Category:British_scientists.
- Leonard_R._Stephens subject Category:Living_people.
- Leonard_R._Stephens type Agent.
- Leonard_R._Stephens type Person.
- Leonard_R._Stephens type Scientist.
- Leonard_R._Stephens type Person.
- Leonard_R._Stephens type Q215627.
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- Leonard_R._Stephens type Person.
- Leonard_R._Stephens comment "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils.".
- Leonard_R._Stephens label "Leonard R. Stephens".
- Leonard_R._Stephens sameAs m.0_85hfl.
- Leonard_R._Stephens sameAs Q15994767.
- Leonard_R._Stephens sameAs Q15994767.
- Leonard_R._Stephens wasDerivedFrom Leonard_R._Stephens?oldid=602191219.
- Leonard_R._Stephens givenName "Leonard R".
- Leonard_R._Stephens isPrimaryTopicOf Leonard_R._Stephens.
- Leonard_R._Stephens name "Len Stephens".
- Leonard_R._Stephens name "Leonard R Stephens".
- Leonard_R._Stephens name "Stephens, Leonard R".
- Leonard_R._Stephens surname "Stephens".