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- Leptomycin abstract "Leptomycin B is a secondary metabolite produced by Streptomyces spp.Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin. However, recent data shows that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors in combination therapy[citation needed].Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human and the fission yeast Schizosaccharomyces pombe. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1 (XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence (NES), by glycosylating a cysteine residue (cysteine 529 in S. pombe). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it inhibits the inactivation of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins[citation needed].Leptomycin A (LPA) was discovered together with LMB. LMB is twice as potent as LPA.".
- Leptomycin iupacName "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-".
- Leptomycin iupacName "17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-".
- Leptomycin iupacName "19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-".
- Leptomycin iupacName "2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid".
- Leptomycin thumbnail Leptomycin_B.svg?width=300.
- Leptomycin wikiPageExternalLink leptomycin_B.htm.
- Leptomycin wikiPageID "4282370".
- Leptomycin wikiPageRevisionID "606358603".
- Leptomycin hasPhotoCollection Leptomycin.
- Leptomycin imagefile "Leptomycin B.svg".
- Leptomycin iupacname "-".
- Leptomycin iupacname "17".
- Leptomycin iupacname "19".
- Leptomycin iupacname "2".
- Leptomycin verifiedrevid "450847443".
- Leptomycin watchedfields "changed".
- Leptomycin subject Category:Antibiotics.
- Leptomycin type Agent114778436.
- Leptomycin type Antibacterial102716205.
- Leptomycin type Antibiotic102716866.
- Leptomycin type Antibiotics.
- Leptomycin type CausalAgent100007347.
- Leptomycin type Drug103247620.
- Leptomycin type Matter100020827.
- Leptomycin type Medicine103740161.
- Leptomycin type PhysicalEntity100001930.
- Leptomycin type Substance100020090.
- Leptomycin type ChemicalCompound.
- Leptomycin type ChemicalSubstance.
- Leptomycin type ChemicalSubstanceType.
- Leptomycin type ChemicalObject.
- Leptomycin type Thing.
- Leptomycin comment "Leptomycin B is a secondary metabolite produced by Streptomyces spp.Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin.".
- Leptomycin label "Leptomycin".
- Leptomycin sameAs m.0btzvx.
- Leptomycin sameAs Q6528191.
- Leptomycin sameAs Q6528191.
- Leptomycin sameAs Leptomycin.
- Leptomycin wasDerivedFrom Leptomycin?oldid=606358603.
- Leptomycin depiction Leptomycin_B.svg.
- Leptomycin isPrimaryTopicOf Leptomycin.