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- Leupeptin abstract "Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases.It is often used during in vitro experiments when a specific enzymatic reaction is being studied. When cells are lysed for these studies, proteases, many of which are contained within lysosomes, are released. These proteases, if freely present in the lysate, would destroy any products from the reaction being studied, and make the experiment uninterpretable. For example, leupeptin could be used in a calpain extraction to keep calpain from being hydrolyzed by specific proteases. The suggested concentration is 1-10 µM (0.5-5 µg/ml).Leupeptin is an organic compound produced by actinomycetes, which inhibits serine, cysteine and threonine proteases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by an excess of substrate.Leupeptin is soluble in water (stable for 1 week at 4 °C and 1 month at −20 °C), ethanol, acetic acid and DMF.It can be given topically for middle and inner ear infections.".
- Leupeptin iupacName "N-Acetyl-leucyl-N-{(5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}-leucinamide".
- Leupeptin thumbnail Leupeptin.svg?width=300.
- Leupeptin wikiPageExternalLink explore.do?structureId=1JRS.
- Leupeptin wikiPageID "5979067".
- Leupeptin wikiPageRevisionID "564020363".
- Leupeptin hasPhotoCollection Leupeptin.
- Leupeptin imagefile "Leupeptin.svg".
- Leupeptin imagename "Stereo, skeletal formula of leupeptin".
- Leupeptin iupacname "N-Acetyl-leucyl-N-{".
- Leupeptin verifiedrevid "443919723".
- Leupeptin watchedfields "changed".
- Leupeptin subject Category:Peptides.
- Leupeptin subject Category:Protease_inhibitors.
- Leupeptin type Abstraction100002137.
- Leupeptin type Amide114724264.
- Leupeptin type Chemical114806838.
- Leupeptin type Compound114818238.
- Leupeptin type Material114580897.
- Leupeptin type Matter100020827.
- Leupeptin type OrganicCompound114727670.
- Leupeptin type Part113809207.
- Leupeptin type Peptide114743046.
- Leupeptin type Peptides.
- Leupeptin type PhysicalEntity100001930.
- Leupeptin type Relation100031921.
- Leupeptin type Substance100019613.
- Leupeptin type ChemicalCompound.
- Leupeptin type ChemicalSubstance.
- Leupeptin type ChemicalObject.
- Leupeptin type Thing.
- Leupeptin comment "Leupeptin, also known as N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases.It is often used during in vitro experiments when a specific enzymatic reaction is being studied. When cells are lysed for these studies, proteases, many of which are contained within lysosomes, are released.".
- Leupeptin label "Leupeptin".
- Leupeptin label "ロイペプチン".
- Leupeptin sameAs ロイペプチン.
- Leupeptin sameAs m.0fhv82.
- Leupeptin sameAs Q11350119.
- Leupeptin sameAs Q11350119.
- Leupeptin sameAs Leupeptin.
- Leupeptin wasDerivedFrom Leupeptin?oldid=564020363.
- Leupeptin depiction Leupeptin.svg.
- Leupeptin isPrimaryTopicOf Leupeptin.