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- Leydig_cell_hypoplasia abstract "Leydig cell hypoplasia (or aplasia) (LCH), also known as Leydig cell agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated 1 in 1,000,000 biological males. It is characterized by an inability of the body to respond to luteinizing hormone (LH), a gonadotropin which is normally responsible for signaling Leydig cells of the testicles to produce testosterone and other androgen sex hormones. The condition manifests itself as pseudohermaphroditism (partially or fully underdeveloped genitalia), hypergonadotropic hypogonadism (decreased or lack of production of sex steroids by the gonads despite high circulating levels of gonadotropins), reduced or absent puberty (lack of development of secondary sexual characteristics, resulting in sexual infantilism if left untreated), and infertility.Leydig cell hypoplasia does not occur in biological females as they do not have either Leydig cells or testicles. However, the cause of the condition in males, luteinizing hormone insensitivity, does affect females, and because LH plays a role in the female reproductive system, it can result in primary amenorrhea or oligomenorrhea (absent or reduced menstruation), infertility due to anovulation, and ovarian cysts.A related condition is follicle-stimulating hormone (FSH) insensitivity, which presents with similar symptoms to those of Leydig cell hypoplasia but with the symptoms in the respective sexes reversed (i.e., hypogonadism and sexual infantilism in females and merely problems with fertility in males). Despite their similar causes, FSH insensitivity is considerably less common in comparison to LH insensitivity.".
- Leydig_cell_hypoplasia diseasesdb "30830".
- Leydig_cell_hypoplasia medlineplus "http://ghr.nlm.nih.gov/condition/leydig-cell-hypoplasia".
- Leydig_cell_hypoplasia omim "238320".
- Leydig_cell_hypoplasia wikiPageExternalLink leydig-cell-hypoplasia.
- Leydig_cell_hypoplasia wikiPageID "36053724".
- Leydig_cell_hypoplasia wikiPageRevisionID "592325823".
- Leydig_cell_hypoplasia diseasesdb "30830".
- Leydig_cell_hypoplasia hasPhotoCollection Leydig_cell_hypoplasia.
- Leydig_cell_hypoplasia medlineplus leydig-cell-hypoplasia.
- Leydig_cell_hypoplasia name "Leydig cell hypoplasia".
- Leydig_cell_hypoplasia omim "238320".
- Leydig_cell_hypoplasia subject Category:Autosomal_recessive_disorders.
- Leydig_cell_hypoplasia subject Category:Endocrine_gonad_disorders.
- Leydig_cell_hypoplasia subject Category:Gonadotropin-releasing_hormone_and_gonadotropins.
- Leydig_cell_hypoplasia subject Category:Intersex_and_medicine.
- Leydig_cell_hypoplasia subject Category:Rare_diseases.
- Leydig_cell_hypoplasia subject Category:Syndromes.
- Leydig_cell_hypoplasia type Disease.
- Leydig_cell_hypoplasia type Situation.
- Leydig_cell_hypoplasia comment "Leydig cell hypoplasia (or aplasia) (LCH), also known as Leydig cell agenesis, is a rare autosomal recessive genetic and endocrine syndrome affecting an estimated 1 in 1,000,000 biological males. It is characterized by an inability of the body to respond to luteinizing hormone (LH), a gonadotropin which is normally responsible for signaling Leydig cells of the testicles to produce testosterone and other androgen sex hormones.".
- Leydig_cell_hypoplasia label "Leydig cell hypoplasia".
- Leydig_cell_hypoplasia sameAs m.0j_7psr.
- Leydig_cell_hypoplasia sameAs Q6538005.
- Leydig_cell_hypoplasia sameAs Q6538005.
- Leydig_cell_hypoplasia wasDerivedFrom Leydig_cell_hypoplasia?oldid=592325823.
- Leydig_cell_hypoplasia isPrimaryTopicOf Leydig_cell_hypoplasia.
- Leydig_cell_hypoplasia name "Leydig cell hypoplasia (or aplasia)".