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- Ligand-gated_ion_channel abstract "Ligand-gated ion channels (LGICs) are a group of transmembrane ion channel proteins which open to allow ions such as Na+, K+, Ca2+, or Cl- to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.These proteins are typically composed of at least two different domains: a transmembrane domain which includes the ion pore, and an extracellular domain which includes the ligand binding location (an allosteric binding site). This modularity has enabled a 'divide and conquer' approach to finding the structure of the proteins (crystallising each domain separately). The function of such receptors located at synapses is to convert the chemical signal of presynaptically released neurotransmitter directly and very quickly into a postsynaptic electrical signal. Many LGICs are additionally modulated by allosteric ligands, by channel blockers, ions, or the membrane potential. LGICs are classified into three superfamilies which lack evolutionary relationship: Cys-loop receptors, Ionotropic glutamate receptors and ATP-gated channels.LGICs can be contrasted with metabotropic receptors (which use second messengers), voltage-gated ion channels (which open and close depending on membrane potential), and stretch-activated ion channels (which open and close depending on mechanical deformation of the cell membrane).".
- Ligand-gated_ion_channel symbol "Neur_chan_memb".
- Ligand-gated_ion_channel thumbnail LGIC.png?width=300.
- Ligand-gated_ion_channel wikiPageExternalLink LGICdb.php.
- Ligand-gated_ion_channel wikiPageExternalLink LGICNomenclature.jsp.
- Ligand-gated_ion_channel wikiPageID "1351369".
- Ligand-gated_ion_channel wikiPageRevisionID "602504729".
- Ligand-gated_ion_channel caption "Ligand-gated ion channel".
- Ligand-gated_ion_channel hasPhotoCollection Ligand-gated_ion_channel.
- Ligand-gated_ion_channel interpro "IPR006029".
- Ligand-gated_ion_channel name "Neurotransmitter-gated ion-channel transmembrane region".
- Ligand-gated_ion_channel opmFamily "14".
- Ligand-gated_ion_channel opmProtein "2".
- Ligand-gated_ion_channel pfam "PF02932".
- Ligand-gated_ion_channel prosite "PDOC00209".
- Ligand-gated_ion_channel scop "1".
- Ligand-gated_ion_channel symbol "Neur_chan_memb".
- Ligand-gated_ion_channel tcdb "1".
- Ligand-gated_ion_channel width "320".
- Ligand-gated_ion_channel subject Category:Electrophysiology.
- Ligand-gated_ion_channel subject Category:Ion_channels.
- Ligand-gated_ion_channel subject Category:Ionotropic_receptors.
- Ligand-gated_ion_channel subject Category:Membrane_biology.
- Ligand-gated_ion_channel subject Category:Molecular_neuroscience.
- Ligand-gated_ion_channel subject Category:Neurochemistry.
- Ligand-gated_ion_channel subject Category:Protein_families.
- Ligand-gated_ion_channel type Abstraction100002137.
- Ligand-gated_ion_channel type Family108078020.
- Ligand-gated_ion_channel type Group100031264.
- Ligand-gated_ion_channel type Organization108008335.
- Ligand-gated_ion_channel type ProteinFamilies.
- Ligand-gated_ion_channel type SocialGroup107950920.
- Ligand-gated_ion_channel type Unit108189659.
- Ligand-gated_ion_channel type YagoLegalActor.
- Ligand-gated_ion_channel type YagoLegalActorGeo.
- Ligand-gated_ion_channel type YagoPermanentlyLocatedEntity.
- Ligand-gated_ion_channel type Biomolecule.
- Ligand-gated_ion_channel type Protein.
- Ligand-gated_ion_channel type BiologicalObject.
- Ligand-gated_ion_channel comment "Ligand-gated ion channels (LGICs) are a group of transmembrane ion channel proteins which open to allow ions such as Na+, K+, Ca2+, or Cl- to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.These proteins are typically composed of at least two different domains: a transmembrane domain which includes the ion pore, and an extracellular domain which includes the ligand binding location (an allosteric binding site).".
- Ligand-gated_ion_channel label "Ionotrope receptor".
- Ligand-gated_ion_channel label "Ionotroper Rezeptor".
- Ligand-gated_ion_channel label "Ligand-gated ion channel".
- Ligand-gated_ion_channel label "Receptor ionotrópico".
- Ligand-gated_ion_channel label "Receptor jonotropowy".
- Ligand-gated_ion_channel label "Recettore ionotropico".
- Ligand-gated_ion_channel label "Récepteur ionotrope".
- Ligand-gated_ion_channel sameAs Ionotroper_Rezeptor.
- Ligand-gated_ion_channel sameAs Receptor_ionotrópico.
- Ligand-gated_ion_channel sameAs Récepteur_ionotrope.
- Ligand-gated_ion_channel sameAs Recettore_ionotropico.
- Ligand-gated_ion_channel sameAs 리간드_개폐_통로.
- Ligand-gated_ion_channel sameAs Ionotrope_receptor.
- Ligand-gated_ion_channel sameAs Receptor_jonotropowy.
- Ligand-gated_ion_channel sameAs m.04vy_7.
- Ligand-gated_ion_channel sameAs Q418536.
- Ligand-gated_ion_channel sameAs Q418536.
- Ligand-gated_ion_channel sameAs Ligand-gated_ion_channel.
- Ligand-gated_ion_channel wasDerivedFrom Ligand-gated_ion_channel?oldid=602504729.
- Ligand-gated_ion_channel depiction LGIC.png.
- Ligand-gated_ion_channel isPrimaryTopicOf Ligand-gated_ion_channel.