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- Lirequinil abstract "Lirequinil (Ro41-3696) is a nonbenzodiazepine hypnotic drug which binds to benzodiazepine sites on the GABAA receptor. In human clinical trials, lirequinil was found to have similar efficacy to zolpidem, with less side effects such as clumsiness and memory impairment. However it was also much slower acting than zolpidem, with peak plasma concentrations not reached until 2.5 hours after oral administration, and its O-desethyl metabolite Ro41-3290 is also active with a half-life of 8 hours. This meant that while effective as a hypnotic, lirequinil failed to prove superior to zolpidem due to producing more next-day sedation, and it has not been adopted for clinical use. It was developed by a team at Hoffmann-La Roche in the 1990s.".
- Lirequinil atcPrefix "none".
- Lirequinil casNumber "143943-73-1".
- Lirequinil fdaUniiCode "2VUW1087AD".
- Lirequinil iupacName "10-chloro-1-[(3S)-3-ethoxypyrrolidine-1-carbonyl]-3-phenyl-6,7-dihydrobenzo[a]quinolizin-4-one".
- Lirequinil pubchem "3045375".
- Lirequinil thumbnail Lirequinil_structure.png?width=300.
- Lirequinil wikiPageID "28913346".
- Lirequinil wikiPageRevisionID "592200626".
- Lirequinil atcPrefix "none".
- Lirequinil c "26".
- Lirequinil casNumber "143943".
- Lirequinil chemspiderid "2308119".
- Lirequinil cl "1".
- Lirequinil h "25".
- Lirequinil hasPhotoCollection Lirequinil.
- Lirequinil inchi "1".
- Lirequinil inchikey "CBSWRAUYCIIUEI-FQEVSTJZBN".
- Lirequinil iupacName "10".
- Lirequinil molecularWeight "448.941".
- Lirequinil n "2".
- Lirequinil o "3".
- Lirequinil pubchem "3045375".
- Lirequinil smiles "CCO[C@H]1CCNCC2=C3C4=CC=CCCl".
- Lirequinil stdinchi "1".
- Lirequinil stdinchikey "CBSWRAUYCIIUEI-FQEVSTJZSA-N".
- Lirequinil unii "2".
- Lirequinil verifiedfields "changed".
- Lirequinil verifiedrevid "451564522".
- Lirequinil width "200".
- Lirequinil subject Category:Sedatives.
- Lirequinil type Agent114778436.
- Lirequinil type CausalAgent100007347.
- Lirequinil type Drug103247620.
- Lirequinil type DrugOfAbuse103248958.
- Lirequinil type Matter100020827.
- Lirequinil type Medicine103740161.
- Lirequinil type PhysicalEntity100001930.
- Lirequinil type Sedative104166553.
- Lirequinil type Sedatives.
- Lirequinil type Substance100020090.
- Lirequinil type Drug.
- Lirequinil type FunctionalSubstance.
- Lirequinil comment "Lirequinil (Ro41-3696) is a nonbenzodiazepine hypnotic drug which binds to benzodiazepine sites on the GABAA receptor. In human clinical trials, lirequinil was found to have similar efficacy to zolpidem, with less side effects such as clumsiness and memory impairment. However it was also much slower acting than zolpidem, with peak plasma concentrations not reached until 2.5 hours after oral administration, and its O-desethyl metabolite Ro41-3290 is also active with a half-life of 8 hours.".
- Lirequinil label "Lirequinil".
- Lirequinil sameAs m.0dgn4lt.
- Lirequinil sameAs Q6557635.
- Lirequinil sameAs Q6557635.
- Lirequinil sameAs Lirequinil.
- Lirequinil wasDerivedFrom Lirequinil?oldid=592200626.
- Lirequinil depiction Lirequinil_structure.png.
- Lirequinil isPrimaryTopicOf Lirequinil.