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- Lisofylline abstract "Lisofylline (LSF) is a synthetic small molecule with novel anti-inflammatory properties. LSF can effectively prevent type 1 diabetes in preclinical models and improves the function and viability of isolated or transplanted pancreatic islets. It is a metabolite of pentoxifylline.As well, LSF improves cellular mitochondrial function and blocks interleukin-12 (IL-12) signaling and STAT-4 activation in target cells and tissues. IL-12 and STAT-4 activation are important pathways linked to inflammation and autoimmune damage to insulin producing cells. Therefore, LSF and related analogs could provide a new therapeutic approach to prevent or reverse type 1 diabetes. LSF also directly reduces glucose-induced changes in human kidney cells suggesting that LSF and analogs have the potential to treat the complications associated with diabetes.".
- Lisofylline casNumber "100324-81-0".
- Lisofylline fdaUniiCode "L1F2Q2X956".
- Lisofylline iupacName "1-[(5R)-5-Hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione".
- Lisofylline pubchem "501254".
- Lisofylline thumbnail Lisofylline.svg?width=300.
- Lisofylline wikiPageExternalLink 1174.
- Lisofylline wikiPageExternalLink diabetes-drug.cfm.
- Lisofylline wikiPageExternalLink query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12242464&dopt=Abstract.
- Lisofylline wikiPageID "5478118".
- Lisofylline wikiPageRevisionID "553954291".
- Lisofylline c "13".
- Lisofylline casNumber "100324".
- Lisofylline chembl "1411".
- Lisofylline chemspiderid "438549".
- Lisofylline h "20".
- Lisofylline hasPhotoCollection Lisofylline.
- Lisofylline iupacName "1".
- Lisofylline molecularWeight "280.32".
- Lisofylline n "4".
- Lisofylline o "3".
- Lisofylline pubchem "501254".
- Lisofylline smiles "O=C2NC".
- Lisofylline stdinchi "1".
- Lisofylline stdinchikey "NSMXQKNUPPXBRG-SECBINFHSA-N".
- Lisofylline synonyms "1".
- Lisofylline unii "L1F2Q2X956".
- Lisofylline verifiedfields "changed".
- Lisofylline verifiedrevid "462092166".
- Lisofylline subject Category:Anti-inflammatory_agents.
- Lisofylline subject Category:Xanthines.
- Lisofylline type Abstraction100002137.
- Lisofylline type Chemical114806838.
- Lisofylline type Compound114818238.
- Lisofylline type Material114580897.
- Lisofylline type Matter100020827.
- Lisofylline type OrganicCompound114727670.
- Lisofylline type Part113809207.
- Lisofylline type PhysicalEntity100001930.
- Lisofylline type Relation100031921.
- Lisofylline type Substance100019613.
- Lisofylline type Xanthine115113050.
- Lisofylline type Xanthines.
- Lisofylline type Drug.
- Lisofylline type FunctionalSubstance.
- Lisofylline comment "Lisofylline (LSF) is a synthetic small molecule with novel anti-inflammatory properties. LSF can effectively prevent type 1 diabetes in preclinical models and improves the function and viability of isolated or transplanted pancreatic islets. It is a metabolite of pentoxifylline.As well, LSF improves cellular mitochondrial function and blocks interleukin-12 (IL-12) signaling and STAT-4 activation in target cells and tissues.".
- Lisofylline label "Lisofylline".
- Lisofylline sameAs m.0dnm8q.
- Lisofylline sameAs Q15409404.
- Lisofylline sameAs Q15409404.
- Lisofylline sameAs Lisofylline.
- Lisofylline wasDerivedFrom Lisofylline?oldid=553954291.
- Lisofylline depiction Lisofylline.svg.
- Lisofylline isPrimaryTopicOf Lisofylline.
