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- Lofentanil abstract "Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil. This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives such as ohmefentanyl, the stereoisomerism of lofentanil is very important, with some stereoisomers being much more potent than others.Lofentanil is very similar to carfentanil in effects, but has a longer duration of action. This makes it unsuitable for most practical applications, with carfentanil being the preferred agent for tranquilizing large animals, and short-acting derivatives such as sufentanil or remifentanil being preferred for medical use in human surgical procedures. The long duration and high lipophilicity of lofentanil has been suggested as an advantage for certain types of analgesia, but the main application for lofentanil at the present time is research into opioid receptors.Side effects from lofentanil would be predicted to be similar to other potent fentanyl analogues, and would include sedation, euphoria, nausea, and pronounced itching and respiratory depression. Side effects from lofentanil might be particularly problematic given its reportedly long duration of action. Another side effect which is characteristic of fentanyl and its derivatives is their tendency to rapidly induce tolerance, due to their high binding affinity triggering rapid internalization of chronically activated opiate receptors. This might be expected to be a particular problem with lofentanil as it is not only one of the most potent drugs in the series, but also is longer acting than most other fentanyl analogues, meaning that development of tolerance triggered by receptor over-activation is likely to be especially rapid.".
- Lofentanil atcPrefix "none".
- Lofentanil casNumber "61380-40-3".
- Lofentanil fdaUniiCode "7H7YQ564XV".
- Lofentanil iupacName "methyl (3S,4R)-3-methyl-1-(2-phenylethyl)-4-[phenyl(propionyl)amino]piperidine-4-carboxylate".
- Lofentanil pubchem "10070040".
- Lofentanil thumbnail Lofentanil.svg?width=300.
- Lofentanil wikiPageID "12790638".
- Lofentanil wikiPageRevisionID "544914843".
- Lofentanil atcPrefix "none".
- Lofentanil c "25".
- Lofentanil casNumber "61380".
- Lofentanil chembl "28198".
- Lofentanil chemspiderid "8245580".
- Lofentanil h "32".
- Lofentanil hasPhotoCollection Lofentanil.
- Lofentanil inchi "1".
- Lofentanil inchikey "IMYHGORQCPYVBZ-NLFFAJNJBT".
- Lofentanil iupacName "methyl -3-methyl-1--4-[phenylamino]piperidine-4-carboxylate".
- Lofentanil molecularWeight "408.533".
- Lofentanil n "2".
- Lofentanil o "3".
- Lofentanil pubchem "10070040".
- Lofentanil smiles "O=C[C@]3CCNC[C@H]3C".
- Lofentanil stdinchi "1".
- Lofentanil stdinchikey "IMYHGORQCPYVBZ-NLFFAJNJSA-N".
- Lofentanil synonyms "Lofentanil; (methyl -1--4 --3-methylpiperidine-4-carboxylate)".
- Lofentanil unii "7".
- Lofentanil verifiedfields "changed".
- Lofentanil verifiedrevid "462093198".
- Lofentanil width "140".
- Lofentanil subject Category:Anilines.
- Lofentanil subject Category:Carboxylate_esters.
- Lofentanil subject Category:Janssen_Pharmaceutica.
- Lofentanil subject Category:Mu-opioid_agonists.
- Lofentanil subject Category:Piperidines.
- Lofentanil subject Category:Propionamides.
- Lofentanil subject Category:Synthetic_opioids.
- Lofentanil type Abstraction100002137.
- Lofentanil type AliphaticCompound114601294.
- Lofentanil type Amine114739004.
- Lofentanil type Aniline114754505.
- Lofentanil type Anilines.
- Lofentanil type CarboxylateEsters.
- Lofentanil type Chemical114806838.
- Lofentanil type Compound114818238.
- Lofentanil type Ester114850483.
- Lofentanil type Material114580897.
- Lofentanil type Matter100020827.
- Lofentanil type MethaneSeries114951377.
- Lofentanil type OrganicCompound114727670.
- Lofentanil type Part113809207.
- Lofentanil type PhysicalEntity100001930.
- Lofentanil type Relation100031921.
- Lofentanil type Substance100019613.
- Lofentanil type Drug.
- Lofentanil type DrugProduct.
- Lofentanil type FunctionalSubstance.
- Lofentanil comment "Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil.".
- Lofentanil label "Lofentanil".
- Lofentanil label "Lofentanil".
- Lofentanil sameAs Lofentanil.
- Lofentanil sameAs m.02x51qv.
- Lofentanil sameAs Q3836402.
- Lofentanil sameAs Q3836402.
- Lofentanil sameAs Lofentanil.
- Lofentanil wasDerivedFrom Lofentanil?oldid=544914843.
- Lofentanil depiction Lofentanil.svg.
- Lofentanil isPrimaryTopicOf Lofentanil.