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- Long-chain-fatty-acid—CoA_ligase abstract "The Long chain fatty acyl-CoA synthetase enzyme is a member of the ligase family that activates the breakdown of complex fatty acids. Long chain fatty acyl-CoA synthetase plays a crucial role in intermediary metabolism by catalyzing the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate. It is an enzyme present in all organisms from bacteria to humans. It catalyzes the pre-step reaction for β-oxidation of fatty acids or can be incorporated in phospholipids. Long chain fatty acyl-CoA synthetase, LC-FACS, plays a role in the physiological regulation of various cellular functions via the production of long chain fatty acyl-CoA esters, which reportedly have affected protein transport, enzyme activation, protein acylation, cell signaling, and transcriptional regulation. The formation of fatty acyl-CoA is catalyzed in two steps: a stable intermediate of fatty acyl-AMP molecule and then the product is formed—fatty acid acyl-CoA molecule.Fatty acyl CoA synthetase catalyzes the activation of a long fatty acid chain to a fatty acyl CoA, requiring the energy of 1 ATP to AMP and pyrophosphate. This step uses 2 "ATP equivalents" because pyrophosphate is cleaved into 2 molecules of inorganic phosphate, breaking a high-energy phosphate bond.".
- Long-chain-fatty-acid—CoA_ligase thumbnail PDB_1v26_EBI.jpg?width=300.
- Long-chain-fatty-acid—CoA_ligase wikiPageID "9924262".
- Long-chain-fatty-acid—CoA_ligase wikiPageRevisionID "592469014".
- Long-chain-fatty-acid—CoA_ligase altsymbols "FACL2".
- Long-chain-fatty-acid—CoA_ligase arm "q".
- Long-chain-fatty-acid—CoA_ligase band "35".
- Long-chain-fatty-acid—CoA_ligase caption "Long chain fatty acyl-CoA synthetase homodimer from Thermus thermophilus.".
- Long-chain-fatty-acid—CoA_ligase casNumber "9013".
- Long-chain-fatty-acid—CoA_ligase chromosome "4".
- Long-chain-fatty-acid—CoA_ligase ecNumber "6.2".
- Long-chain-fatty-acid—CoA_ligase ecnumber "6.2".
- Long-chain-fatty-acid—CoA_ligase entrezgene "2180".
- Long-chain-fatty-acid—CoA_ligase goCode "31957".
- Long-chain-fatty-acid—CoA_ligase hgncid "3569".
- Long-chain-fatty-acid—CoA_ligase iubmbEcNumber "6".
- Long-chain-fatty-acid—CoA_ligase name ACSL1.
- Long-chain-fatty-acid—CoA_ligase name "long-chain-fatty-acid—CoA ligase".
- Long-chain-fatty-acid—CoA_ligase omim "152425".
- Long-chain-fatty-acid—CoA_ligase refseq "NM_001995".
- Long-chain-fatty-acid—CoA_ligase symbol ACSL1.
- Long-chain-fatty-acid—CoA_ligase uniprot "P33121".
- Long-chain-fatty-acid—CoA_ligase type Biomolecule.
- Long-chain-fatty-acid—CoA_ligase type Enzyme.
- Long-chain-fatty-acid—CoA_ligase type BiologicalObject.
- Long-chain-fatty-acid—CoA_ligase comment "The Long chain fatty acyl-CoA synthetase enzyme is a member of the ligase family that activates the breakdown of complex fatty acids. Long chain fatty acyl-CoA synthetase plays a crucial role in intermediary metabolism by catalyzing the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate. It is an enzyme present in all organisms from bacteria to humans.".
- Long-chain-fatty-acid—CoA_ligase label "Acyl-coenzyme A synthétase".
- Long-chain-fatty-acid—CoA_ligase label "Fettsäure-CoA-Ligasen".
- Long-chain-fatty-acid—CoA_ligase label "Long-chain-fatty-acid—CoA ligase".
- Long-chain-fatty-acid—CoA_ligase sameAs Long-chain-fatty-acid%E2%80%94CoA_ligase.
- Long-chain-fatty-acid—CoA_ligase sameAs Fettsäure-CoA-Ligasen.
- Long-chain-fatty-acid—CoA_ligase sameAs Acyl-coenzyme_A_synthétase.
- Long-chain-fatty-acid—CoA_ligase sameAs Q1409319.
- Long-chain-fatty-acid—CoA_ligase sameAs Q1409319.
- Long-chain-fatty-acid—CoA_ligase wasDerivedFrom Long-chain-fatty-acid—CoA_ligase?oldid=592469014.
- Long-chain-fatty-acid—CoA_ligase depiction PDB_1v26_EBI.jpg.