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- Lonidamine abstract "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.Clinical trials of lonidamine in combination with other anticancer agents for a variety of cancers has begun. This is due to its proven ability to inhibit energy metabolism in cancer cells, and to enhance the activity of anticancer agents.Lonidamine has been used in the treatment of brain tumours in combination with radiotherapy and temozolomide. Results showed that a combination of temozolomide and lonidamine at clinically achievable, low plasma concentrations, could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours.A derivative of lonidamine, gamendazole, is in testing as a possible male contraceptive pill.".
- Lonidamine atcPrefix "L01".
- Lonidamine atcSuffix "XX07".
- Lonidamine casNumber "50264-69-2".
- Lonidamine fdaUniiCode "U78804BIDR".
- Lonidamine iupacName "1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid".
- Lonidamine pubchem "39562".
- Lonidamine thumbnail Lonidamine.svg?width=300.
- Lonidamine wikiPageID "20362464".
- Lonidamine wikiPageRevisionID "592311880".
- Lonidamine atcPrefix "L01".
- Lonidamine atcSuffix "XX07".
- Lonidamine c "15".
- Lonidamine casNumber "50264".
- Lonidamine cl "2".
- Lonidamine h "10".
- Lonidamine hasPhotoCollection Lonidamine.
- Lonidamine iupacName "1".
- Lonidamine kegg "D07257".
- Lonidamine molecularWeight "321.158".
- Lonidamine n "2".
- Lonidamine o "2".
- Lonidamine pubchem "39562".
- Lonidamine unii "U78804BIDR".
- Lonidamine verifiedrevid "444558328".
- Lonidamine watchedfields "changed".
- Lonidamine subject Category:Antineoplastic_drugs.
- Lonidamine subject Category:Indazoles.
- Lonidamine type Agent114778436.
- Lonidamine type Antineoplastic102722458.
- Lonidamine type AntineoplasticDrugs.
- Lonidamine type CausalAgent100007347.
- Lonidamine type CytotoxicDrug103157987.
- Lonidamine type Drug103247620.
- Lonidamine type Matter100020827.
- Lonidamine type Medicine103740161.
- Lonidamine type PhysicalEntity100001930.
- Lonidamine type Substance100020090.
- Lonidamine type Drug.
- Lonidamine type DrugProduct.
- Lonidamine type FunctionalSubstance.
- Lonidamine comment "Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase.".
- Lonidamine label "Lonidamina".
- Lonidamine label "Lonidamine".
- Lonidamine sameAs Lonidamina.
- Lonidamine sameAs m.04zyy7s.
- Lonidamine sameAs Q3836670.
- Lonidamine sameAs Q3836670.
- Lonidamine sameAs Lonidamine.
- Lonidamine wasDerivedFrom Lonidamine?oldid=592311880.
- Lonidamine depiction Lonidamine.svg.
- Lonidamine isPrimaryTopicOf Lonidamine.