Matches in DBpedia 2014 for { <http://dbpedia.org/resource/MDA5> ?p ?o. }
Showing items 1 to 24 of
24
with 100 items per page.
- MDA5 abstract "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.".
- MDA5 entrezgene "64135".
- MDA5 wikiPageID "14818992".
- MDA5 wikiPageRevisionID "598752977".
- MDA5 hasPhotoCollection MDA5.
- MDA5 requireManualInspection "no".
- MDA5 summaryText "DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp , are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein . Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.".
- MDA5 updateCitations "yes".
- MDA5 updatePage "yes".
- MDA5 updateProteinBox "yes".
- MDA5 updateSummary "yes".
- MDA5 subject Category:Intracellular_receptors.
- MDA5 subject Category:RIG-I-like_receptors.
- MDA5 type Biomolecule.
- MDA5 type Protein.
- MDA5 type BiologicalObject.
- MDA5 comment "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length.".
- MDA5 label "MDA5".
- MDA5 label "MDA5".
- MDA5 sameAs m.03gz0__.
- MDA5 sameAs Q6715117.
- MDA5 sameAs Q6715117.
- MDA5 wasDerivedFrom MDA5?oldid=598752977.
- MDA5 isPrimaryTopicOf MDA5.