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- MDia1 abstract "mDia1 (also known as Dia1, Drf1 for Diaphanous-related formin-1, Diaph1, KIAA4062, p140mDia, mKIAA4062, D18Wsu154e) is a protein. It is the mouse version of the diaphanous homolog 1 of Drosophila. It belongs to the protein family called the formins and is a Rho effector. It localizes to the mitotic spindle and midbody, plays a role in stress fiber and filopodia formation, phagocytosis, activation of serum response factor, a transcription factor, and formation of adherens junction. mDia1 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments. The gene encoding mDia1 is located on Chromosome 18 of Mus musculus and named Diap1. mDia1 is highly homologous to Drosophila diaphanous, regulating the cytokinetic ring during cytokinesis. Homologues in other species are known as well, like the human DIAP1, budding yeast's Bni1 or Cdc12p of S. pombe.".
- MDia1 pdb "1z2c".
- MDia1 refseq "NP_031884.1".
- MDia1 symbol "DRF1".
- MDia1 symbol "mDia1".
- MDia1 thumbnail 1z2c_asr_r_500.jpeg?width=300.
- MDia1 uniprot "o08808".
- MDia1 wikiPageExternalLink www.pdb.org.
- MDia1 wikiPageID "27405535".
- MDia1 wikiPageRevisionID "595484606".
- MDia1 altsymbols "DRF1".
- MDia1 caption "Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP".
- MDia1 hasPhotoCollection MDia1.
- MDia1 name "Protein diaphanous homolog 1".
- MDia1 pdb "1".
- MDia1 refseq "NP_031884.1".
- MDia1 symbol "mDia1".
- MDia1 uniprot "o08808".
- MDia1 subject Category:Animal_proteins.
- MDia1 subject Category:Cell_cycle.
- MDia1 subject Category:Mouse_genes.
- MDia1 type Biomolecule.
- MDia1 type Protein.
- MDia1 type BiologicalObject.
- MDia1 comment "mDia1 (also known as Dia1, Drf1 for Diaphanous-related formin-1, Diaph1, KIAA4062, p140mDia, mKIAA4062, D18Wsu154e) is a protein. It is the mouse version of the diaphanous homolog 1 of Drosophila. It belongs to the protein family called the formins and is a Rho effector. It localizes to the mitotic spindle and midbody, plays a role in stress fiber and filopodia formation, phagocytosis, activation of serum response factor, a transcription factor, and formation of adherens junction.".
- MDia1 label "MDia1".
- MDia1 sameAs m.0cmcq4w.
- MDia1 sameAs Q6715229.
- MDia1 sameAs Q6715229.
- MDia1 wasDerivedFrom MDia1?oldid=595484606.
- MDia1 depiction 1z2c_asr_r_500.jpeg.
- MDia1 isPrimaryTopicOf MDia1.
- MDia1 name "Protein diaphanous homolog 1".