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- MEK_inhibitor abstract "A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers. (See MAPK/ERK pathway#Clinical significance.)Hence MEK inhibitors have potential for treatment of some cancers, especially BRAF-mutated melanoma, and KRAS/BRAF mutated colorectal cancer.Some MEK inhibitors: Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma. Also studied in combination with BRAF inhibitor dabrafenib to treat BRAF-mutated melanoma. Selumetinib, had a phase 2 clinical trial for non-small cell lung cancer (NSCLC) which demonstrated an improvement in PFS, and is now in phase III development in KRAS mutation positive NSCLC (SELECT-1,NCT01933932). Other clinical trials underway include uveal melanoma, and differentiated thyroid carcinoma. MEK162, had phase 1 trial for biliary tract cancer and melanoma PD-325901, for breast cancer, colon cancer, and melanoma Cobimetinib or XL518, in a Phase III trial, in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma CI-1040, PD035901↑ ↑ ↑ ↑ ↑ ↑".
- MEK_inhibitor wikiPageID "37952149".
- MEK_inhibitor wikiPageRevisionID "585429629".
- MEK_inhibitor hasPhotoCollection MEK_inhibitor.
- MEK_inhibitor subject Category:Cell_signaling.
- MEK_inhibitor subject Category:Experimental_cancer_drugs.
- MEK_inhibitor subject Category:Protein_kinase_inhibitors.
- MEK_inhibitor comment "A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers. (See MAPK/ERK pathway#Clinical significance.)Hence MEK inhibitors have potential for treatment of some cancers, especially BRAF-mutated melanoma, and KRAS/BRAF mutated colorectal cancer.Some MEK inhibitors: Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma.".
- MEK_inhibitor label "MEK inhibitor".
- MEK_inhibitor sameAs m.0p8v7c6.
- MEK_inhibitor sameAs Q17142288.
- MEK_inhibitor sameAs Q17142288.
- MEK_inhibitor wasDerivedFrom MEK_inhibitor?oldid=585429629.
- MEK_inhibitor isPrimaryTopicOf MEK_inhibitor.