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- MTEP abstract "3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs.MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant, analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used.MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine.".
- MTEP casNumber "329205-68-7".
- MTEP iupacName "3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine".
- MTEP pubchem "9794218".
- MTEP thumbnail Mtep.png?width=300.
- MTEP wikiPageID "20245287".
- MTEP wikiPageRevisionID "592596794".
- MTEP alt "Skeletal formula".
- MTEP alt "Space-filling model".
- MTEP c "11".
- MTEP casNumber "329205".
- MTEP h "8".
- MTEP hasPhotoCollection MTEP.
- MTEP image "MTEP-3D-spacefill.png".
- MTEP iupacName "3".
- MTEP molecularWeight "200.26".
- MTEP n "2".
- MTEP pubchem "9794218".
- MTEP s "1".
- MTEP smiles "CC1=NCC#CC2=CN=CC=C2".
- MTEP verifiedrevid "424696647".
- MTEP watchedfields "changed".
- MTEP width "200".
- MTEP subject Category:Alkynes.
- MTEP subject Category:Pyridines.
- MTEP subject Category:Receptor_antagonists.
- MTEP subject Category:Thiazoles.
- MTEP type Abstraction100002137.
- MTEP type Acetylene114600742.
- MTEP type AliphaticCompound114601294.
- MTEP type Alkynes.
- MTEP type Base114618253.
- MTEP type Chemical114806838.
- MTEP type Compound114818238.
- MTEP type Material114580897.
- MTEP type Matter100020827.
- MTEP type OrganicCompound114727670.
- MTEP type Part113809207.
- MTEP type PhysicalEntity100001930.
- MTEP type Pyridine114692510.
- MTEP type Pyridines.
- MTEP type Relation100031921.
- MTEP type Substance100019613.
- MTEP type Drug.
- MTEP type DrugProduct.
- MTEP type FunctionalSubstance.
- MTEP comment "3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5.".
- MTEP label "MTEP".
- MTEP sameAs m.04zzpbb.
- MTEP sameAs Q13566097.
- MTEP sameAs Q13566097.
- MTEP sameAs MTEP.
- MTEP wasDerivedFrom MTEP?oldid=592596794.
- MTEP depiction Mtep.png.
- MTEP isPrimaryTopicOf MTEP.