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- Marginal_zone_B-cell abstract "Marginal zone B cells are noncirculating mature B cells that segregate anatomically into the marginal zone (MZ) of the spleen. This region contains multiple subtypes of macrophages, dendritic cells, and the MZ B cells; it is not fully formed until 2 to 3 weeks after birth in rodents and 1 to 2 years in humans. The MZ B cells within this region typically express high levels of sIgM, CD21, CD1, CD9 with low to negligible levels of sIgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells.Similar to B1 B cells, MZ B cells can be rapidly recruited into the early adaptive immune responses in a T cell independent manner. The MZ B cells are especially well positioned as a first line of defense against systemic blood-borne antigens that enter the circulation and become trapped in the spleen. It is believed they are especially reactive to bacterial cell wall components and self-antigens which are the products of aging. MZ B cells also display a lower activation threshold than their FO B cell counterparts with heightened propensity for plasma cell differentiation that contributes further to the accelerated primary antibody response.In specimens where the tyrosine kinase for Pyk-2 has been knocked-out, marginal zone B-cells will fail to develop while B-1 cells will still be present.MZ B-cells are the only B-cells dependent on NOTCH2 signaling for proliferation.".
- Marginal_zone_B-cell wikiPageID "19603252".
- Marginal_zone_B-cell wikiPageRevisionID "603023061".
- Marginal_zone_B-cell hasPhotoCollection Marginal_zone_B-cell.
- Marginal_zone_B-cell subject Category:Lymphocytes.
- Marginal_zone_B-cell type BloodCell105449268.
- Marginal_zone_B-cell type Cell100006484.
- Marginal_zone_B-cell type FreePhagocyte105451265.
- Marginal_zone_B-cell type Leukocyte105449959.
- Marginal_zone_B-cell type LivingThing100004258.
- Marginal_zone_B-cell type Lymphocyte105451384.
- Marginal_zone_B-cell type Lymphocytes.
- Marginal_zone_B-cell type Object100002684.
- Marginal_zone_B-cell type Phagocyte105450888.
- Marginal_zone_B-cell type PhysicalEntity100001930.
- Marginal_zone_B-cell type SomaticCell105430628.
- Marginal_zone_B-cell type Whole100003553.
- Marginal_zone_B-cell comment "Marginal zone B cells are noncirculating mature B cells that segregate anatomically into the marginal zone (MZ) of the spleen. This region contains multiple subtypes of macrophages, dendritic cells, and the MZ B cells; it is not fully formed until 2 to 3 weeks after birth in rodents and 1 to 2 years in humans.".
- Marginal_zone_B-cell label "Marginal zone B-cell".
- Marginal_zone_B-cell sameAs m.04n46c3.
- Marginal_zone_B-cell sameAs Q6760431.
- Marginal_zone_B-cell sameAs Q6760431.
- Marginal_zone_B-cell sameAs Marginal_zone_B-cell.
- Marginal_zone_B-cell wasDerivedFrom Marginal_zone_B-cell?oldid=603023061.
- Marginal_zone_B-cell isPrimaryTopicOf Marginal_zone_B-cell.