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- Metamizole abstract "Metamizole (INN), or dipyrone (BAN, USAN), is a ampyrone sulfonate analgesic (pain reliever), antispasmodic (spasm reliever) and antipyretic (fever reducer) similar to paracetamol in that it has minimal anti-inflammatory effects and which is most commonly given orally or parenterally (by injection) to prevent and treat pain related to surgery or for the treatment of acute pain. It was first introduced into clinical use in Germany in 1921 and for many years it was available over-the-counter in most countries, until its toxicities became so readily apparent, although in some countries it is available over-the-counter, its use is usually restricted in developed countries, due to its potential for causing toxic reactions.Metamizole is marketed under various trade names, including Algozone, Algocalmin, Algopyrin, Analgin, Dipirona, Novalgin, Neo-Melubrina and Optalgin. Metamizole has been used for decades in many European (excluding the UK, but including most of continental Europe, including Germany, Italy, Russia, Spain and Turkey), Asian (China, India, Indonesia and Thailand included), African (including South Africa) and South American (including Argentina and Brazil) countries, despite this, it has been found to have a potentially fatal side effect of agranulocytosis (a dangerously compromised immune system; its rate varies significantly country-to-country), aplastic anaemia and hypersensitivity reactions (like allergic reactions such as anaphylaxis).It was once widely combined with various other active ingredients, but since concerns over its safety have been raised in the late 1960s and 1970s its use in combination products has been in decline and in some countries, banned. Regardless, some national medical authorities (such as in Australia and United States of America) have withdrawn metamizole from the market altogether or have restricted it to be available only with a prescription, although it remains available over the counter in some countries.Despite its potential haematologic (blood-related) toxicity (that is potential for causing blood dyscrasias) it produces no clinically relevant effects in the way of kidney toxicity, cardiovascular toxicity and GI toxicity when compared to non-steroidal anti-inflammatory drugs (NSAIDs). Unlike paracetamol and similarly to the NSAIDs it can trigger bronchospasm or anaphylaxis, especially in those with asthma.".
- Metamizole atcPrefix "N02".
- Metamizole atcSuffix "BB02".
- Metamizole bioavailability "100.0".
- Metamizole casNumber "68-89-3".
- Metamizole casSupplemental "(sodium salt)".
- Metamizole chEBI "59033".
- Metamizole drugbank "DB04817".
- Metamizole fdaUniiCode "VSU62Z74ON".
- Metamizole iupacName "[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid".
- Metamizole pubchem "80254".
- Metamizole thumbnail Metamizole2DACS.svg?width=300.
- Metamizole wikiPageID "2988884".
- Metamizole wikiPageRevisionID "606697649".
- Metamizole atcPrefix "N02".
- Metamizole atcSuffix "BB02".
- Metamizole bioavailability "100.0".
- Metamizole c "13".
- Metamizole casNumber "68".
- Metamizole chebi "59033".
- Metamizole chembl "487894".
- Metamizole chemspiderid "6000".
- Metamizole drugName "Metamizole".
- Metamizole drugbank "DB04817".
- Metamizole eliminationHalfLife "15240.0".
- Metamizole excretion "Urine , faeces .".
- Metamizole h "16".
- Metamizole hasPhotoCollection Metamizole.
- Metamizole image "Metamizole3Dan.gif".
- Metamizole inchi "1".
- Metamizole inchikey "DJGAAPFSPWAYTJ-REWHXWOFAG".
- Metamizole iupacName "[methylamino] methanesulfonic acid".
- Metamizole legalStatus "Over-the-counter ; prescription-only ; withdrawn".
- Metamizole metabolism "Liver".
- Metamizole molecularWeight "333.337".
- Metamizole n "3".
- Metamizole na "1".
- Metamizole o "4".
- Metamizole pregnancyCategory "None assigned; no evidence of teratogenicity in animal studies, but use in the third trimester may cause adverse effects in the newborn or ductus arteriosus due to its weak NSAID activity.".
- Metamizole proteinBound "48".
- Metamizole pubchem "80254".
- Metamizole routesOfAdministration "Oral, IM, IV, rectal".
- Metamizole s "1".
- Metamizole smiles "[Na+].[O-]SCNC".
- Metamizole stdinchi "1".
- Metamizole stdinchikey "DJGAAPFSPWAYTJ-UHFFFAOYSA-M".
- Metamizole tradename "Analgin, Berlosin".
- Metamizole unii "VSU62Z74ON".
- Metamizole verifiedrevid "464373286".
- Metamizole watchedfields "changed".
- Metamizole subject Category:Analgesics.
- Metamizole subject Category:Antipyretics.
- Metamizole subject Category:Pyrazolones.
- Metamizole subject Category:Sulfonates.
- Metamizole subject Category:Withdrawn_drugs.
- Metamizole type Agent114778436.
- Metamizole type Analgesic102707683.
- Metamizole type Analgesics.
- Metamizole type Antipyretic102723595.
- Metamizole type Antipyretics.
- Metamizole type CausalAgent100007347.
- Metamizole type Drug103247620.
- Metamizole type Matter100020827.
- Metamizole type Medicine103740161.
- Metamizole type PhysicalEntity100001930.
- Metamizole type Substance100020090.
- Metamizole type WithdrawnDrugs.
- Metamizole type Drug.
- Metamizole type DrugProduct.
- Metamizole type FunctionalSubstance.
- Metamizole comment "Metamizole (INN), or dipyrone (BAN, USAN), is a ampyrone sulfonate analgesic (pain reliever), antispasmodic (spasm reliever) and antipyretic (fever reducer) similar to paracetamol in that it has minimal anti-inflammatory effects and which is most commonly given orally or parenterally (by injection) to prevent and treat pain related to surgery or for the treatment of acute pain.".
- Metamizole label "Metamizol".
- Metamizole label "Metamizol".
- Metamizole label "Metamizol".
- Metamizole label "Metamizol".
- Metamizole label "Metamizol".
- Metamizole label "Metamizole".
- Metamizole label "Metamizolo".
- Metamizole label "Noramidopyrine".
- Metamizole label "Метамизол натрия".
- Metamizole label "安乃近".
- Metamizole sameAs Metamizol.
- Metamizole sameAs Metamizol.
- Metamizole sameAs Metamizol.
- Metamizole sameAs Metamizol.
- Metamizole sameAs Noramidopyrine.
- Metamizole sameAs Metamizolo.
- Metamizole sameAs 설피린.
- Metamizole sameAs Metamizol.
- Metamizole sameAs Metamizol.
- Metamizole sameAs Metamizol.
- Metamizole sameAs m.08j19g.
- Metamizole sameAs Q422761.
- Metamizole sameAs Q422761.
- Metamizole sameAs DB04817.
- Metamizole sameAs Metamizole.
- Metamizole wasDerivedFrom Metamizole?oldid=606697649.
- Metamizole depiction Metamizole2DACS.svg.
- Metamizole isPrimaryTopicOf Metamizole.
- Metamizole name "Metamizole".