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- Methocarbamol abstract "Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Under the trade name Robaxin, it is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. Methocarbamol produces its clinical effects through agonism of the GABAA receptor, resulting in an exaggerated effect of gamma-aminobutyric acid (GABA) which occurs naturally in the brain. Activation of the GABA receptor increases the amount of chloride ions that pass through the chloride channel of cells, resulting in a depressant effect by reducing the cells action potential (like dimming a light, the cell continues to function but at a lower capacity). This mechanism is very similar to that of barbiturates, benzodiazepines, z-drugs, alcohol, and GABA analogues such as GHB. Most GABAergics require GABA as a co-factor in order to activate the chloride channel, however methocarbamol can activate the chloride channel even in the absence of GABA; this ability is called direct agonism (as opposed to allosteric agonism) and is relatively rare among GABAergic drugs, being shared only by other carbamate derivatives and a handful of other substances.".
- Methocarbamol atcPrefix "M03".
- Methocarbamol atcSuffix "BA03".
- Methocarbamol casNumber "532-03-6".
- Methocarbamol chEBI "6832".
- Methocarbamol drugbank "DB00423".
- Methocarbamol fdaUniiCode "125OD7737X".
- Methocarbamol iupacName "(RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate".
- Methocarbamol pubchem "4107".
- Methocarbamol thumbnail Methocarbamol_structure.svg?width=300.
- Methocarbamol wikiPageID "2073410".
- Methocarbamol wikiPageRevisionID "605999848".
- Methocarbamol atcPrefix "M03".
- Methocarbamol atcSuffix "BA03".
- Methocarbamol c "11".
- Methocarbamol casNumber "0532-03-06".
- Methocarbamol chebi "6832".
- Methocarbamol chembl "1201117".
- Methocarbamol chemspiderid "3964".
- Methocarbamol drugbank "DB00423".
- Methocarbamol eliminationHalfLife "4464.0".
- Methocarbamol h "15".
- Methocarbamol hasPhotoCollection Methocarbamol.
- Methocarbamol inchi "1".
- Methocarbamol inchikey "GNXFOGHNGIVQEH-UHFFFAOYAU".
- Methocarbamol iupacName "-2".
- Methocarbamol kegg "D00402".
- Methocarbamol legalStatus "OTC".
- Methocarbamol legalUs "Rx-only".
- Methocarbamol medlineplus "a682579".
- Methocarbamol metabolism "Hepatic".
- Methocarbamol molecularWeight "241.241".
- Methocarbamol n "1".
- Methocarbamol o "5".
- Methocarbamol pregnancyCategory "x".
- Methocarbamol pubchem "4107".
- Methocarbamol routesOfAdministration "Oral, intravenous".
- Methocarbamol smiles "O=CN".
- Methocarbamol stdinchi "1".
- Methocarbamol stdinchikey "GNXFOGHNGIVQEH-UHFFFAOYSA-N".
- Methocarbamol unii "125".
- Methocarbamol verifiedfields "changed".
- Methocarbamol verifiedrevid "457287029".
- Methocarbamol watchedfields "changed".
- Methocarbamol width "200".
- Methocarbamol subject Category:Alcohols.
- Methocarbamol subject Category:Carbamates.
- Methocarbamol subject Category:Muscle_relaxants.
- Methocarbamol subject Category:Phenol_ethers.
- Methocarbamol subject Category:Veterinary_drugs.
- Methocarbamol type Drug.
- Methocarbamol type DrugProduct.
- Methocarbamol type FunctionalSubstance.
- Methocarbamol comment "Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. Under the trade name Robaxin, it is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. Methocarbamol produces its clinical effects through agonism of the GABAA receptor, resulting in an exaggerated effect of gamma-aminobutyric acid (GABA) which occurs naturally in the brain.".
- Methocarbamol label "Methocarbamol".
- Methocarbamol label "Methocarbamol".
- Methocarbamol label "メトカルバモール".
- Methocarbamol sameAs Methocarbamol.
- Methocarbamol sameAs メトカルバモール.
- Methocarbamol sameAs m.06k98p.
- Methocarbamol sameAs Q411456.
- Methocarbamol sameAs Q411456.
- Methocarbamol sameAs Methocarbamol.
- Methocarbamol sameAs DB00423.
- Methocarbamol sameAs 4107.
- Methocarbamol wasDerivedFrom Methocarbamol?oldid=605999848.
- Methocarbamol depiction Methocarbamol_structure.svg.
- Methocarbamol isPrimaryTopicOf Methocarbamol.