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- Methoxyflurane abstract "Methoxyflurane (INN), formerly marketed as Penthrane by Abbott Laboratories, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction by Joseph F. Artusio et al in 1960 until the late 1970s. It was first synthesized in the late 1940s by William T. Miller and his team of chemists following their involvement in the Manhattan Project.Methoxyflurane is an extremely potent and highly lipid soluble anesthetic agent, characterized by very slow induction (onset of action) and emergence (offset or dissipation) times. It is non-flammable, has relatively mild hemodynamic effects, and it does not predispose the heart to rhythm disturbances. It is however a significant respiratory depressant. Methoxyflurane has powerful analgesic (pain-relieving) properties at well below full anesthetic doses. It was utilized in self-administration devices for obstetric analgesia, in a manner that foreshadowed the patient-controlled analgesia infusion pumps of today.The biodegradation of methoxyflurane produces inorganic fluoride and dichloroacetic acid (DCAA). The combined effects of these two compounds may be responsible for the toxicity of methoxyflurane to some of the major organs of the human body. Methoxyflurane was determined to be nephrotoxic (damaging to the kidneys) in a dose-dependent response and hepatotoxic (damaging to the liver) at anesthetic doses in 1973, and the drug was abandoned as a general anesthetic in the late 1970s. In 1999, the manufacturer discontinued distribution of methoxyflurane in the United States and Canada, and on September 6, 2005, the Food and Drug Administration determined that it should be withdrawn from the market for safety concerns. It is however still used in Australia as an emergency analgesic for the initial management of pain due to acute trauma, as well as for brief painful procedures such as changing of wound dressings or for transport of injured people.".
- Methoxyflurane atcPrefix "N02".
- Methoxyflurane atcSuffix "BG09".
- Methoxyflurane casNumber "76-38-0".
- Methoxyflurane drugbank "DB01028".
- Methoxyflurane fdaUniiCode "30905R8O7B".
- Methoxyflurane iupacName "2,2-dichloro-1,1-difluoro-1-methoxyethane".
- Methoxyflurane pubchem "4116".
- Methoxyflurane thumbnail Methoxyflurane.svg?width=300.
- Methoxyflurane wikiPageExternalLink books?id=-YI9P2DLe9UC.
- Methoxyflurane wikiPageExternalLink v=onepage&q=%22Graham's%20law%22%20%22uranium%20enrichment%22&f=false.
- Methoxyflurane wikiPageExternalLink v=onepage&q&f=false.
- Methoxyflurane wikiPageExternalLink ?id=mYQxRY9umjcC&printsec=frontcover&dq=Drug+Discovery+history&cd=1.
- Methoxyflurane wikiPageExternalLink CCB_030.pdf.
- Methoxyflurane wikiPageExternalLink npgd0389.html.
- Methoxyflurane wikiPageExternalLink penthrox.
- Methoxyflurane wikiPageExternalLink abbott_analgizer.html.
- Methoxyflurane wikiPageID "5365919".
- Methoxyflurane wikiPageRevisionID "579123157".
- Methoxyflurane atcPrefix "N02".
- Methoxyflurane atcSuffix "BG09".
- Methoxyflurane c "3".
- Methoxyflurane casNumber "76".
- Methoxyflurane chembl "1341".
- Methoxyflurane chemspiderid "3973".
- Methoxyflurane cl "2".
- Methoxyflurane drugbank "DB01028".
- Methoxyflurane f "2".
- Methoxyflurane h "4".
- Methoxyflurane hasPhotoCollection Methoxyflurane.
- Methoxyflurane image "Methoxyflurane-3D-balls.png".
- Methoxyflurane inchi "1".
- Methoxyflurane inchikey "RFKMCNOHBTXSMU-UHFFFAOYAI".
- Methoxyflurane iupacName "22".
- Methoxyflurane kegg "D00544".
- Methoxyflurane legalAu "S4".
- Methoxyflurane metabolism "70.0".
- Methoxyflurane molecularWeight "164.966".
- Methoxyflurane o "1".
- Methoxyflurane pregnancyAu "C".
- Methoxyflurane pregnancyUs "C".
- Methoxyflurane pubchem "4116".
- Methoxyflurane routesOfAdministration "Inhalation".
- Methoxyflurane smiles "ClCCOC".
- Methoxyflurane stdinchi "1".
- Methoxyflurane stdinchikey "RFKMCNOHBTXSMU-UHFFFAOYSA-N".
- Methoxyflurane synonyms "(2,2-dichloro-1,1-difluoroethyl methyl ether)".
- Methoxyflurane unii "30905".
- Methoxyflurane verifiedrevid "457473565".
- Methoxyflurane watchedfields "changed".
- Methoxyflurane subject Category:Analgesics.
- Methoxyflurane subject Category:Ethers.
- Methoxyflurane subject Category:General_anesthetics.
- Methoxyflurane subject Category:Organochlorides.
- Methoxyflurane subject Category:Organofluorides.
- Methoxyflurane type Agent114778436.
- Methoxyflurane type Analgesic102707683.
- Methoxyflurane type Analgesics.
- Methoxyflurane type Anesthetic102710766.
- Methoxyflurane type CausalAgent100007347.
- Methoxyflurane type Drug103247620.
- Methoxyflurane type GeneralAnesthetic103433434.
- Methoxyflurane type GeneralAnesthetics.
- Methoxyflurane type Matter100020827.
- Methoxyflurane type Medicine103740161.
- Methoxyflurane type PhysicalEntity100001930.
- Methoxyflurane type Substance100020090.
- Methoxyflurane type Drug.
- Methoxyflurane type DrugProduct.
- Methoxyflurane type FunctionalSubstance.
- Methoxyflurane comment "Methoxyflurane (INN), formerly marketed as Penthrane by Abbott Laboratories, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction by Joseph F. Artusio et al in 1960 until the late 1970s. It was first synthesized in the late 1940s by William T.".
- Methoxyflurane label "Methoxyfluran".
- Methoxyflurane label "Methoxyflurane".
- Methoxyflurane label "Metossiflurano".
- Methoxyflurane label "Metoxiflurano".
- Methoxyflurane label "Méthoxyflurane".
- Methoxyflurane label "Метоксифлуран".
- Methoxyflurane label "ميثوكسي فلوران".
- Methoxyflurane sameAs Methoxyfluran.
- Methoxyflurane sameAs Méthoxyflurane.
- Methoxyflurane sameAs Metossiflurano.
- Methoxyflurane sameAs Metoxiflurano.
- Methoxyflurane sameAs m.0dhm4v.
- Methoxyflurane sameAs Q411594.
- Methoxyflurane sameAs Q411594.
- Methoxyflurane sameAs DB01028.
- Methoxyflurane sameAs Methoxyflurane.
- Methoxyflurane wasDerivedFrom Methoxyflurane?oldid=579123157.
- Methoxyflurane depiction Methoxyflurane.svg.
- Methoxyflurane isPrimaryTopicOf Methoxyflurane.