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- Microcystin abstract "Microcystins are cyclic nonribosomal peptides produced by cyanobacteria (e.g.Microcystis aeruginosa and Planktothrix). They are cyanotoxins and can be very toxic for plants and animals including humans. Their hepatotoxicity may cause serious damage to the liver. Microcystins can strongly inhibit protein phosphatases type 1 (PP1) and 2A (PP2A), and are linked to pansteatitis. Microcystins consist of several uncommon non-proteinogenic amino acids such as dehydroalanine derivatives and the special β-amino acid ADDA, (all-S,all-E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid).Microcystin-LR is one of over 80 known toxic variants and is the most studied by chemists, pharmacologists, biologists and ecologists. Microcystin-containing 'blooms' are a problem worldwide, including China, Brazil, Australia, the United States and much of Europe. Once ingested, microcystin travels to the liver, via the bile acid transport system, where most is stored; though some remains in the blood stream and may contaminate tissue. Microcystin binds covalently to protein phosphatases thus disrupting cellular control processes.There appears to be inadequate information to assess carcinogenic potential of microcystins by applying EPA Guidelines for Carcinogen Risk Assessment. A few studies suggest that there may be a relationship between liver and colorectral cancers and the occurrence of cyanobacteria in drinking water in China (Yu et al., 1989; Zhou et al., 2002). Evidence is, however, limited due to limited ability to accurately assess and measure exposure.".
- Microcystin thumbnail Microcystin-LR.png?width=300.
- Microcystin wikiPageExternalLink en.
- Microcystin wikiPageID "476265".
- Microcystin wikiPageRevisionID "590234177".
- Microcystin hasPhotoCollection Microcystin.
- Microcystin subject Category:Cyanotoxins.
- Microcystin subject Category:Peptides.
- Microcystin type Abstraction100002137.
- Microcystin type Amide114724264.
- Microcystin type Chemical114806838.
- Microcystin type Compound114818238.
- Microcystin type Material114580897.
- Microcystin type Matter100020827.
- Microcystin type OrganicCompound114727670.
- Microcystin type Part113809207.
- Microcystin type Peptide114743046.
- Microcystin type Peptides.
- Microcystin type PhysicalEntity100001930.
- Microcystin type Relation100031921.
- Microcystin type Substance100019613.
- Microcystin comment "Microcystins are cyclic nonribosomal peptides produced by cyanobacteria (e.g.Microcystis aeruginosa and Planktothrix). They are cyanotoxins and can be very toxic for plants and animals including humans. Their hepatotoxicity may cause serious damage to the liver. Microcystins can strongly inhibit protein phosphatases type 1 (PP1) and 2A (PP2A), and are linked to pansteatitis.".
- Microcystin label "Microcistina".
- Microcystin label "Microcystin".
- Microcystin label "Microcystine".
- Microcystin label "Microcystine".
- Microcystin label "Microcystine".
- Microcystin label "Mikrocystyna".
- Microcystin label "ミクロシスチン".
- Microcystin sameAs Microcystine.
- Microcystin sameAs Microcistina.
- Microcystin sameAs Microcystine.
- Microcystin sameAs ミクロシスチン.
- Microcystin sameAs Microcystine.
- Microcystin sameAs Mikrocystyna.
- Microcystin sameAs m.02f3gb.
- Microcystin sameAs Q424720.
- Microcystin sameAs Q424720.
- Microcystin sameAs Microcystin.
- Microcystin wasDerivedFrom Microcystin?oldid=590234177.
- Microcystin depiction Microcystin-LR.png.
- Microcystin isPrimaryTopicOf Microcystin.